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Chemicals that activate or inhibit Smo (shown in the left and right sides of the figure, respectively) may interfere with embryonic development. For example,

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Presentation on theme: "Chemicals that activate or inhibit Smo (shown in the left and right sides of the figure, respectively) may interfere with embryonic development. For example,"— Presentation transcript:

1 Chemicals that activate or inhibit Smo (shown in the left and right sides of the figure, respectively) may interfere with embryonic development. For example, the plant alkaloid cyclopamine inhibits Smo and causes cyclopia, a birth defect, in lambs. Smo inhibitors are potentially anticarcinogenic, whereas Smo activators may promote carcinogenesis by increased Hh signaling. Inactivating mutation of Ptch, the main inhibitor of Hh signaling, typically occurs in basal cell carcinoma of the skin that may be induced by UV and ionizing radiation, as well as arsenic exposure (Tang et al., 2007). SAG, Smoothened Agonist; SANT-1, Smoothened Antagonist 1. Source: Mechanisms of Toxicity, Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e Citation: Klaassen CD. Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e; 2012 Available at: Accessed: November 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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