1. Depiction of meiotic crossing over and linkage analysis
Depiction of meiotic crossing over and linkage analysis. The upper panel shows two copies of one chromosome (one in solid line and one in dashed line) from an individual before (above) and after (below) meiotic crossing over. The individual is heterozygous for a disease locus with a normal allele (open square) and a disease allele (filled square) and is heterozygous for four DNA markers with alleles A/B, F/G, K/L, and R/S at 0, 1, 10, and >50 cM from the disease locus, respectively. The lower panel depicts analysis in a family for an autosomal dominant disorder. The DNA marker with K/L alleles at 10 cM from the disease locus on chromosome 4 and another DNA marker with Y/Z alleles on chromosome 7 are depicted. The chromosomes 4 and 7 for each parent are shown and the genotypes given for each family member. The disease phenotype is inherited from the father with the L allele for the DNA marker except for the last child who represents a crossover of the type shown in the upper panel. See text for discussion.
Source: Genetics, Biochemistry, and Molecular Bases of Variant Human Phenotypes, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 06, 2017
Copyright © 2017 McGraw-Hill Education. All rights reserved