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Investigation of markers to indicate and distinguish death due to Alcoholic Ketoacidosis, Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State using.

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Presentation on theme: "Investigation of markers to indicate and distinguish death due to Alcoholic Ketoacidosis, Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State using."— Presentation transcript:

1 Investigation of markers to indicate and distinguish death due to Alcoholic Ketoacidosis, Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State using post-mortem samples  Joanna Hockenhull, Waljit Dhillo, Rebecca Andrews, Sue Paterson  Forensic Science International  Volume 214, Issue 1, Pages (January 2012) DOI: /j.forsciint Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Typical diagnostic features of Alcoholic Ketoacidosis (AKA), Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS). Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Distribution of beta-hydroxybutyrate (βHB) concentration in diabetics, alcoholics, alcoholic diabetics, unknown and all cases where pathologically significant (>250μg/mL) (m=median). Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Scatter plot showing the relationship between beta-hydroxybutyrate (βHB) and acetone for all cases with acetone detected above limit of detection (2mg/dL). Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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