1. Tuberculosis Chemotherapy with Hydrazine Derivatives of Isonicotinic Acid 
IRVING J. SELIKOFF, M.D., F.C.C.P., EDWARD H. ROBITZEK, M.D., F.C.C.P. 
Diseases of the Chest 
Volume 21, Issue 4, Pages (April 1952)
DOI: /chest
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

2. FIGURE 1a, CASE 1
E.M. X-ray film of October 16, 1951 shows extensive bilateral exudate and extensive left upper lobe cavitation.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

3. FIGURE 1d, CASE 1
E.M. X-ray film of January 8, 1952 shows considerable clearing of exudate. The cavitation persists.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

4. FIGURE 1b, CASE 1
E.M. The temperature decline is complete within the second week.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

5. FIGURE 1c, CASE 1
E.M. The extraordinary weight gain is well illustrated by this graph.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

6. FIGURE 2a, CASE 2
M.N. X-ray film of March 11, 1949 showing chronic bilateral upper lobe cavitation of long duration.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

7. FIGURE 2b, CASE 2
M.N. X-ray film of September 21, 1951 showing little change of chronic disease during previous two and one-half years.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

8. FIGURE 2d, CASE 2
M.N. X-ray film of January 11, 1952 shows diminution of cavities in both upper lobes after three months of therapy. These had previously shown no change over long period of time on serial films.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

9. FIGURE 2c, CASE 2
M.N. Gradual weight gain even in long-standing chronic disease is illustrated by this graph.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

10. FIGURE 3
Composite graphs of patients on 2 mg. and 4 mg./K. of Marsilid. Weight gain occurs with the former dose but is accelerated on doubling the dose. Comparison shows that a group beginning on the higher dosage level gained weight more rapidly.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

11. FIGURE 4
Composite weight graph of all patients taking Marsilid and Rimifon.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

12. FIGURE 5a, CASE P.R.
X-ray film on September 14, 1951, illustrating status at onset of therapy.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

13. FIGURE 5c, CASE P.R.
X-ray film of January 7, Cavity is still visible, although cough and expectoration are no longer present.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

14. FIGURE 5b, CASE P.R.
Graph illustrating weight gain of 28 pounds in nine weeks of therapy.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

15. FIGURE 6a, CASE E.S.
X-ray film on November 8, 1951 showing bilateral caseous-pneumonic disease. Sputum positive on unconcentrated smear.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

16. FIGURE 6c, CASE E.S.
Roentgenogram of January 7, 1952 showing marked disease in cavity and considerable reabsorption of exudate. Sputum negative since second week of therapy.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

17. FIGURE 6b, CASE E.S.
Weight graph of case E.S. showing gain of 53 pounds in 10 weeks of therapy.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

18. FIGURE 7a, CASE H.M.
X-ray film of December 17, 1951 showing bilateral upper lobe cavitation at onset of therapy.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

19. FIGURE 7c, CASE H.M.
X-ray film of January 11, 1951 shows diminution in cavity size and reabsorption of exudate. However, despite negative sputum, cavity is still open.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions

20. FIGURE 7b, CASE H.M.
Graph showing weight curve of patient H.M. Slow weight loss ceased with institution of therapy and in seven weeks there has been 23 pounds of weight gained.
Diseases of the Chest  , DOI: ( /chest )
Copyright © 1952 The American College of Chest Physicians Terms and Conditions