1. Neural Basis of the Perception and Estimation of Time
SE367 Homework 3

2. Previous works
Scalar timing theory(Gibbon et al.1984) Neurophysiological model of timing(Matell &
Meck 2004)

3. EVIDENCE FAVORING A COMMON TIMING MECHANISM
Work started in late 19th century
Time dependent and time independent sources Temporal processing

4. EVIDENCE FAVORING A UBIQUITOUS TIMING ABILITY OF CORTICAL NETWORKS
Timing is an inherent computational ability of every cortical circuit
Psychophysical experiments suggest that sensory timing is local.

5. AN INTERMEDIATE HYPOTHESIS
Merchant and colleagues (2008c)

7. NEUROPHYSIOLOGICAL BASIS OF TIME ESTIMATION: RAMPING ACTIVITY IN THE CORE TIMING CIRCUIT
Most studies report climbing activity during a variety of timing tasks.

9. NEUROANATOMICAL AND NEUROCHEMICAL SYSTEMS FOR INTERVAL TIMING
The centrality of the striatum and dopamine (DA) neurotransmission in explicit timing.
Frontoparietal systems may govern attention and working memory, which interact with timekeeping processes

10. FUNCTIONAL SIGNIFICANCE OF BRAIN CIRCUITS THAT GOVERN INTERVAL TIMING
Pairwise subtractions of brain activation during time discrimination (T), pitch discrimination (P), and the sensorimotor control (C) tasks were conducted for each period.

12. ILLUSIONS OF TIME
Emerging neuroimaging research suggests that the mechanisms may be partially context dependent.

13. CONCLUSIONS

14. THANK YOU!