1. AN ATTEMPT TO REVERSE CANCER DRUG RESISTANCE
Systems Biology for Translational Medicine
Prospective Project Partnership Meeting
AN ATTEMPT TO REVERSE CANCER DRUG RESISTANCE
Melis KARTAL YANDIM
Faculty of Medicine, Basic Medical Sciences

2. Field of Study / Technical Experience
Keywords:
Cancer Molecular Biology
Multidrug Resistance Mechanisms
Reversal of Drug Resistance
Bioactive Sphingolipids
Combination Therapies

3. Kartal Yandim, et al. Critical Reviews in Biotechnology [Epub ahead of print]

4. Adapted: Ogretmen & Hannun Nature Reviews Cancer, 2004, 4:604-616

5. Projects
Combination of therapeutic agents with bioactive sphingolipids in CML cell lines
Synergistic cytotoxic & apoptotic effects
Expression levels of Ceramide-metabolizing genes in CML patients

8. Project Idea / Contribution Fields
Proposed project title:
Ceramide nanoliposomes for leukemia patients
Generation of novel SK/GCS inhibitors for leukemia patients
List of the fields you may participate and/or techniques you may offer:
Testing the effects of a novel agent on (cancer) cells & proposing the possible signaling pathways;
Cell Culture
Primary Cell Isolation & Culture
Cell Viability / Cellular Cytotoxicity
Cell Death / Apoptotic Assays
Cell Cycle Analysis
Gene Expression Analyses (RNA & Protein level)
Transfection (siRNA-GFP- cell migration)

9. Department of Basic Medical Sciences,
Contact Details
Melis KARTAL YANDIM
Faculty of Medicine,
Department of Basic Medical Sciences,
Medical Biology