1. An Introduction to Derwent World Drug Index
Richard Lambert
Pharmaceutical Product Manager

2. World Drug Index - Background
World Drug Index launched in 1994
Originated from Standard Drug File (SDF)
Coverage back to 1964
Contains only named compounds, including Trial Preparation Codes
Released on a quarterly cumulative basis

3. World Drug Index - What is it?
Integrated drug database containing
marketed drugs
drugs in development
new chemical entities (NCE’s) from scientific literature or reported at conferences
Text and structure searchable
20 searchable fields with controlled keywords
Standard conventions for selection and structure input

4. World Drug Index - Coverage/Selection Guidelines
Source Materials
Literature articles from over 1,200 journals
Conference proceedings (approx. 20 per year)
Pharmacopoeias and Approved Name Lists
Selection Criteria
All named compounds from the Derwent Drug File
All named compounds from Conference Fast-Track
Named compounds from pharmacopoeias and approved name lists (e.g. USAN and INN)

5. World Drug Index - Statistics
Over 64,000 drug records
4000 new records per annum
16,000 updates to existing records per annum
Over 203,000 synonyms
12,000 Approved Names
34,000 Trial Preparation Codes
144,000 Trade Names/Trivial Names
13,000 Combination Names
Over 20,000 source references (added since 1994)

6. World Drug Index - Data fields
Derwent Drug Name
Structure
Derwent Registry Name
Pharmacological Activity / Mechanism of Action
Reference
Chemical Substructure keywords
Synonyms
Biomedical Data

7. World Drug Index - Features/Uses
Structure/sub-structure activity relationships
Archive reference file for marketed and development drugs
Information on drug manufacturers and countries of origin/sale
Trade name and synonym searching

8. World Drug Index - Daylight’s Implementation
Full Version
Lite Version
Includes:
Structural data
Synonyms
Activity
Excludes:
Mechanism of Action
Biomedical Information

9. World Drug Index - HTML Version
Simple intuitive interface
Text fields
Names
CAS numbers
Smiles
Structure searchable using GRINS
Exact
Substructure
Superstructure