1. PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C
PARP-1 Inhibition Rescues Short Lifespan in Hyperglycemic C. Elegans And Improves GLP-1 Secretion in Human Cells
Xia Qianghua 1 ;Lu Sumei 1 ;Ostrovsky Julian 1 ;E. McCormack Shana 2, 3, 4 ;J. Falk Marni 1, 3 ;F. A. Grant Struan 1, 2, 3, 4 ;
1 Division of Human Genetics, The Children#cod#x02019;s Hospital of Philadelphia, Philadelphia, PA 19104, USA ; 2 Division of Endocrinology and Diabetes, The Children#cod#x02019;s Hospital of Philadelphia, Philadelphia, PA 19104, USA ; 3 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; 4 Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ;
Figure 6. Olaparib treatment of endoendocrine intestinal cells increases expression of A TCF7L2 , B GCG and C PC1 . Relative levels of individual gene expression in the control and the Olaparib treatment groups determined by quantitative PCR with GAPDH normalization. Values are the mean of three independent experiments. Error bars indicate standard deviation. Statistical analyses were performed by two-tailed Student#cod#x00027;s t-test and significance is denoted by asterisks where #cod#x0002A; P #cod#x0003C;0.05 or #cod#x0002A;#cod#x0002A; P #cod#x0003C;0.01.
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