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Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis.

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Presentation on theme: "Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis."— Presentation transcript:

1 Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis coupled to time-of- flight mass spectrometry  Rossella Gottardo, Ameriga Fanigliulo, Daniela Sorio, Eloisa Liotta, Federica Bortolotti, Franco Tagliaro  Forensic Science International  Volume 216, Issue 1, Pages (March 2012) DOI: /j.forsciint Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Fig. 1 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 1. Identified peaks: MT 11.2min, m/z , EDDP; MT 11.3 and 11.5min, m/z and respectively, peaks from matrix; MT 11.6min, m/z , methadone; MT 11.9min, m/z , des-methyl-levomepromazine-sulfoxide; MT 12.7min, m/z , levomepromazine-sulfoxide; MT 13.0min, m/z , m-chlorophenylpiperazine; MT 13.8min, m/z , nicotine. For analytical conditions, see text. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 2. Identified peaks: MT 10.1min, m/z , peak from matrix; MT 10.4min, m/z , des-methyl-citalopram; MT 10.8min, m/z , escitalopram; MT 11.3min, m/z , cocaethylene; MT 11.5min, m/z , cocaine; MT 11.6min, m/z , m-chlorophenylpiperazine. For analytical conditions, see text. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 3. Identified peaks: MT 12.4 and 12.6min, m/z and respectively, peaks from matrix; MT 13.5min, m/z , escitalopram; MT 14.1min, m/z , cocaethylene; MT 14.4min, m/z , cocaine; MT 15.1min, m/z , benzoylecgonine; MT 15.3min, m/z , nicotine. For analytical conditions, see text. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 4. Identified peaks: MT 11.7min, m/z , EDDP; MT 12.1min, m/z , methadone; MT 14.4min, m/z , codeine; MT 14.9, m/z , 6-MAM; MT 15.0min, m/z , morphine. For analytical conditions, see text. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 5. Identified peaks: MT 11.5min, m/z , des-methyl-citalopram; MT 12.0min, m/z , citalopram; MT 12.9min, m/z , rivastigmine; MT 13.0min, m/z , rivastigmine metabolite. For analytical conditions, see text. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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