Presentation is loading. Please wait.

Presentation is loading. Please wait.

The REDOXS© Study REducing Deaths from OXidative Stress Part 1 of 3

Published byKathleen Morgan Modified over 6 years ago

Similar presentations

Presentation on theme: "The REDOXS© Study REducing Deaths from OXidative Stress Part 1 of 3"— Presentation transcript:

1 The REDOXS© Study REducing Deaths from OXidative Stress Part 1 of 3
REDOXS Training The REDOXS© Study REducing Deaths from OXidative Stress Part 1 of 3 Sponsor Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD October 2007

2 Administration of Study Supplements

3 Parenteral Supplement
Study Groups Enteral Supplement Parenteral Supplement GLN +AOX Glutamine + AOX Dipeptiven + Selenium AOX AOX only Placebo + Selenium GLN Glutamine only Dipeptiven + Placebo Placebo Placebo + Placebo SC blinded Pharmacist unblinded

4 Enteral Study Supplement
EN REDOXS © Formula

5 Parenteral Study Supplements (Dipeptiven and Selenium)
+

6 Enteral Nutrition ENTERAL REDOXS formula PARENTERAL REDOXS formula (but will be in a normal saline type bag) Jevity and ENTERAL REDOXS being “Y”-ed in using Y connector

7 Study Supplements Pharmacist is unblinded Supplements to start ASAP
SS Manual p 4-10 Study Supplements Pharmacist is unblinded Supplements to start ASAP within 24 hrs of admission to ICU within 2 hrs of randomization Duration: 28 days or death or ICU discharge min of 5 days IF transferred to ward, if not until ICU d/c Continuous infusion X 24 hrs but can be doubled up (12 hrs max)

8 Infusion of Supplements
REDOXS Training Infusion of Supplements Parenteral supplements as soon as patient resuscitated 10 ml/hr dedicated central port (eg. one of a triple lumen) can run peripherally if needed (watch for phlebitis) Do NOT infuse with medications; IV fluids, albumin, nutrition OK Enteral supplement NG tube OK or feeding tube 20 ml/hr, can be given via Y connector start regardless of whether MDs want to start enteral nutrition nutrients vs. nutrition October 2007

9 Template of Study Orders Study Supplement Manual Page 11
Imp. Manual: Tools To optimize delivery of supplements Study day 1= ICU admission until end of your flowsheet

10 REDOXS© Teamwork Site Investigator Pharmacist Dietitian
Regulatory Inclusion/exclusion criteria ICU infection adjudication SAE reporting Pharmacist Checking allocation Dispensing Logs Dietitian Optimizing nutrition Monitoring Adequacy Study Coordinator Regulatory Screening/Randomization Pharmacy communication Data collection Supplement monitoring Collaboration with SI SAE reporting Protocol Violation reporting

Download ppt "The REDOXS© Study REducing Deaths from OXidative Stress Part 1 of 3"

Similar presentations

A Randomized Trial of Supplemental Parenteral Nutrition in

A Randomized Trial of Supplemental Parenteral Nutrition in
PEP uP Powerpoint - Long Version

PEP uP Powerpoint - Long Version
The Inter-rater Reliability and Intra-rater Reliability of Bedside Ultrasounds of the Femoral Muscle Thickness Daren K. Heyland, MD, MSc, FRCPC Professor.

The Inter-rater Reliability and Intra-rater Reliability of Bedside Ultrasounds of the Femoral Muscle Thickness Daren K. Heyland, MD, MSc, FRCPC Professor.
Protocol The. I’M HUNGRY! Adequate Nutrition Provides fuel for cellular metabolism Prevents protein/muscle wasting Decreases ventilator time Helps prevent.

Protocol The. I’M HUNGRY! Adequate Nutrition Provides fuel for cellular metabolism Prevents protein/muscle wasting Decreases ventilator time Helps prevent.
The Impact of Enteral Feeding Protocols on Enteral Nutrition Delivery: Results of a multicenter observational study Rupinder Dhaliwal, RD Daren K. Heyland,

The Impact of Enteral Feeding Protocols on Enteral Nutrition Delivery: Results of a multicenter observational study Rupinder Dhaliwal, RD Daren K. Heyland,
The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator.

The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator.
MAIN FEATURES OF THE PEP uP PROTOCOL All patients will receive Peptamen ® Bariatric initially All patients will start on Beneprotein ® -2 packets (14.

MAIN FEATURES OF THE PEP uP PROTOCOL All patients will receive Peptamen ® Bariatric initially All patients will start on Beneprotein ® -2 packets (14.
The REDOXS © Study REducing Deaths from OXidative Stress Dietitian and Pharmacy Training March 2009 Study Chair Dr. Daren Heyland, MD, FRCPC Project Leaders.

The REDOXS © Study REducing Deaths from OXidative Stress Dietitian and Pharmacy Training March 2009 Study Chair Dr. Daren Heyland, MD, FRCPC Project Leaders.
REDOX: A secondary analysis What did we learn? Daren K. Heyland MD Professor of Medicine Queen’s University, Kingston, ON Canada On behalf of the REDOXS.

REDOX: A secondary analysis What did we learn? Daren K. Heyland MD Professor of Medicine Queen’s University, Kingston, ON Canada On behalf of the REDOXS.
The REDOXS © Study REducing Deaths from OXidative Stress Sponsor Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD.

The REDOXS © Study REducing Deaths from OXidative Stress Sponsor Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD.
The REDOXS © Study REducing Deaths from OXidative Stress Study Chair Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD.

The REDOXS © Study REducing Deaths from OXidative Stress Study Chair Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD.
The REDOXS © Study REducing Deaths from OXidative Stress PART 4 of 4 Sponsor Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD.

The REDOXS © Study REducing Deaths from OXidative Stress PART 4 of 4 Sponsor Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD.
Case Report Form Start-up Meeting March 25, 2010 Kingston, ON.

Case Report Form Start-up Meeting March 25, 2010 Kingston, ON.
The REDOXS © Study REducing Deaths from OXidative Stress March 2009 Study Chair Dr. Daren Heyland, MD, FRCPC Project Leaders Rupinder Dhaliwal, RD and.

The REDOXS © Study REducing Deaths from OXidative Stress March 2009 Study Chair Dr. Daren Heyland, MD, FRCPC Project Leaders Rupinder Dhaliwal, RD and.
The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator.

The PEP uP Protocol. I’M HUNGRY!! Adequate Nutrition  Provides fuel for cellular metabolism  Prevents protein/muscle wasting  Decreases ventilator.
Objectives: To optimize the delivery of EN by implementing the PEP uP protocol in sites across North America. We provide practitioners the opportunity.

Objectives: To optimize the delivery of EN by implementing the PEP uP protocol in sites across North America. We provide practitioners the opportunity.
Joint Research & Enterprise Office Training The team, the procedures, the monitor and the Sponsor Lucy H H Parker Clinical Research Governance Manager.

Joint Research & Enterprise Office Training The team, the procedures, the monitor and the Sponsor Lucy H H Parker Clinical Research Governance Manager.
Aims to evaluate different feeding policies for stroke patients: Are oral supplements effective? When should we start tube feeding? Is PEG better than.

Aims to evaluate different feeding policies for stroke patients: Are oral supplements effective? When should we start tube feeding? Is PEG better than.
A RandomizEd Trial of ENtERal Glutamine to MinimIZE Thermal Injury Study Sponsors Dr. Paul Wischmeyer (US) Dr. Dominique Garrel (Canada) Clinical Evaluation.

A RandomizEd Trial of ENtERal Glutamine to MinimIZE Thermal Injury Study Sponsors Dr. Paul Wischmeyer (US) Dr. Dominique Garrel (Canada) Clinical Evaluation.
Study Procedures & Operational Issues Start-up Meeting March 25, 2010 Kingston, ON.

Study Procedures & Operational Issues Start-up Meeting March 25, 2010 Kingston, ON.

Similar presentations

Ads by Google