1. How To Increase Enrollment In Trials
C. Michael Gibson, M.S., M.D.
Chief, Clinical Research, Beth Israel Deaconess CV Division
Chairman, PERFUSE Study Group
Chairman of the Board of WikiDoc Foundation,
The World’s Open Source Textbook of Medicine Viewed 150 Million Times Annually
Harvard Medical
School

2. C. Michael Gibson, MD Consulting: Bristol-Myers Squibb Daiichi Sankyo
Eli Lilly and Company
Portola Pharmaceuticals, Inc.
St. Jude Medical, Inc.
Cytori Therapeutics
The Medicines Company

3. C. Michael Gibson, MD Grant Support:
Bayer Corporation, Angel Medical Systems, Inc., Atrium Medical Corporation, Ikaria, Inc., Lantheus Medical Imaging, Portola Pharmaceuticals, Inc., St. Jude Medical, Inc., Genentech, Inc., Stealth Peptides, Inc., Volcano Therapeutics, Inc, Johnson and Johnson, Walk Vascular, Merck and Company, Inc. and Sanofi-Aventis

4. C. Michael Gibson, MD Honoraria: Merck and Company, Inc.
Regado Bio-Sciences
Baxter International, Inc.
Sanofi-Aventis
Cardiovascular Research Foundation
Consensus Medical Communications

5. Patient Based Strategies
Increase awareness of the trial via:
In-Hospital flyers
Out patient clinic flyers
Local radio: disease state pieces, interviews
Local TV: disease state pieces, special interest stories
Hospital TV
Local newspaper: advertisements, disease state pieces, interviews
Targeted campaigns
Billboards
Hospital portal
Dedicated trial website with appropriate tags & SEO
Twitter
You Tube interviews with appropriate tags
Material must be approved by the IRB!

6. Strategies You Cannot Use
You cannot lead patients to believe that there is a benefit to them personally from participating in the study
Provide any monetary incentive to referring doctors (finders fee)
You cannot provide any monetary incentive to patients for their participation
You can obtain IRB approval to reimburse patients for travel expenses and parking expenses

7. Healthcare Provider Based Strategies
Increase awareness of the trial via:
Same as patient based strategies
Grand rounds
Morning report with housestaff
Targeted strategies
Physician blog
Letters via snail mail
Breakfast / lunch to discuss trial with MDs and RNs
Electronic medical record prompts

8. Strategies You Cannot Use
Provide any monetary incentive to referring doctors (finders fee)

9. Use Of Social Media To Lead Trials