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Newborn SF-1 knockout mice lack adrenal glands and gonads and have female internal genitalia. SF-1 knockout pups and wild-type littermates were sacrificed,

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Presentation on theme: "Newborn SF-1 knockout mice lack adrenal glands and gonads and have female internal genitalia. SF-1 knockout pups and wild-type littermates were sacrificed,"— Presentation transcript:

1 Newborn SF-1 knockout mice lack adrenal glands and gonads and have female internal genitalia. SF-1 knockout pups and wild-type littermates were sacrificed, and the genitourinary tracts were isolated by dissection. A. SF-1 knockout female. B. Wild-type female. C. SF-1 knockout male. D. Wild-type male. The scale bar equals 1 mm. Abbreviations: k, kidney; a, adrenal; o, ovary; t, testis; e, epididymis; od, oviduct. (Reprinted with permission from Luo et al.323 ) Source: Congenital Adrenal Hyperplasia, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 08, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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