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James Watson & Francis Crick

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Presentation on theme: "James Watson & Francis Crick"— Presentation transcript:

1 James Watson & Francis Crick
17.2 – The Structure of Nucleic Acids   DNA – The Double Helix see fig and 17.13, pp

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3 Maurice Wilkins (1916- ) Like Crick, New Zealand-born Wilkins trained as a physicist, and was involved with the Manhattan project to build the nuclear bomb. Wilkins worked on X-ray crystallography of DNA with Franklin at King's College London, although their relationship was strained. He helped to verify Watson and Crick's model, and shared the 1962 Nobel with them.

4 What makes up the double helix?

5 Subunits of the helix: Nucleotides

6 2 types of Nucleotides; Purines & Pyrimidines

7 3 parts of a nucleotide

8 Varying parts in a nucleotide
2 types of sugar All Phospate groups same 5 different nitrogenous bases

9 How nucleotide form helix

10 How nucleotide form helix

11 How nucleotide form helix

12 T-A 2 hydrogen bonds C-G 3 hydrogen bonds

13 Erwin Chargaff ( ) Chargaff discovered the pairing rules of DNA letters, noticing that A matches to T and C to G. He later criticized molecular biology, the discipline he helped invent, as "the practice of biochemistry without a licence", and once described Francis Crick as looking like "a faded racing tout".

14 Replication of DNA. Semi-conservative


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