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James Watson & Francis Crick
17.2 – The Structure of Nucleic Acids DNA – The Double Helix see fig and 17.13, pp
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Maurice Wilkins (1916- ) Like Crick, New Zealand-born Wilkins trained as a physicist, and was involved with the Manhattan project to build the nuclear bomb. Wilkins worked on X-ray crystallography of DNA with Franklin at King's College London, although their relationship was strained. He helped to verify Watson and Crick's model, and shared the 1962 Nobel with them.
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What makes up the double helix?
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Subunits of the helix: Nucleotides
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2 types of Nucleotides; Purines & Pyrimidines
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3 parts of a nucleotide
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Varying parts in a nucleotide
2 types of sugar All Phospate groups same 5 different nitrogenous bases
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How nucleotide form helix
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How nucleotide form helix
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How nucleotide form helix
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T-A 2 hydrogen bonds C-G 3 hydrogen bonds
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Erwin Chargaff ( ) Chargaff discovered the pairing rules of DNA letters, noticing that A matches to T and C to G. He later criticized molecular biology, the discipline he helped invent, as "the practice of biochemistry without a licence", and once described Francis Crick as looking like "a faded racing tout".
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Replication of DNA. Semi-conservative
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