1. SOMATOSENSORY PHYSIOLOGY (PAIN AND TEMPERATURE)

2. Pain and Temperature Pathways Classes of nociceptors
Fast and slow pain
Pain transmission neurons
Gate control theory of pain

3. Pain and Temperature Descending inhibitory pathways
Peripheral mechanisms
Neuropathic pain
Referred pain
Thermoreceptors

4. Anterolateral and Dorsal Column Systems
From Kandel,Schwartz, and Jessell, 2000, 22-14

5. From Kandel,Schwartz, and Jessell, 2000, 24-8

7. Pain Unpleasant sensation or experience Subjective and individualized
Moods and circumstances
Pain and nociceptors

8. Classes of Nociceptors
Thermal nociceptors
Mechanical nociceptors
Polymodal nociceptors

9. Qualities of Fast and Slow Pain

10. Pain Transmission Neurons

11. Gate Control Theory of Pain

13. Descending Inhibitory Pathways

14. Spinal Cord Integration of Nociceptor Afferents and Descending Pathways
From Kandel,Schwartz, and Jessell, 2000, 24-13

15. Opiates Receptors Opiate peptides (morphine, codine)
(gut, respiratory system, descending pathways)
Opiate peptides (morphine, codine)
Endogenous opiate peptides
Enkephalins – descending pathways
Dynorphins – descending pathways
-endorphins – hypothalamus

16. Peripheral Mechanisms
From Kandel,Schwartz, and Jessell, 2000, 24-7

17. Agents That Activate or Sensitize Nociceptors
* Calcitonin gene-related protein (CGRP)

18. Hyperalgesia

19. Neuropathic Pain Phantom Pain Entrapment Lesions
Associated with amputations
Entrapment Lesions
Nerve irritation or inflammation
Thalamic Pain Syndrome
Vascular lesions involving thalamus (VPL)
Patients describe this pain as most excruciating pain ever experienced

20. Referred Pain
From Kandel,Schwartz, and Jessell, 2000, 24-3

21. Thermoreceptors

22. Temperature Sensitive Fibers
From Byrne and Levy 1998

23. From Kandel,Schwartz, and Jessell, 2000, 22-9