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Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray.

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Presentation on theme: "Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray."— Presentation transcript:

1 Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray ionization  Woonyong Kwon, Jin Young Kim, SungIll Suh, Moon Kyo In  Forensic Science International  Volume 221, Issue 1, Pages (September 2012) DOI: /j.forsciint Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Cr analysis on three analytical columns: (a) a C18 column (Capcell Pak C18 MG-II column, 150mm×2.0mm I.D., 5μm), (b) a phenyl column (Allure PFP propyl, 50mm×2.1mm I.D., 5μm), and (c) a multi-mode C18 column (Scherzo SM-C18, 30mm×2.0mm I.D., 3μm). Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Representative LC–MS/MS chromatograms, including (a) blank (distilled water) without IS, (b) blank, (c) positive quality control (QCP), (d) Cr and UA positive, and (e) Cr and UA negative samples. Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 2 Representative LC–MS/MS chromatograms, including (a) blank (distilled water) without IS, (b) blank, (c) positive quality control (QCP), (d) Cr and UA positive, and (e) Cr and UA negative samples. Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 3 Ion suppression evaluated by monitoring the MRM transitions of Cr, Cr-d3 and UA during post-column infusion of 10ng/min of the analytes and IS for (a) blank (distilled water) and (b) positive quality control (QCP) samples. Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 4 Distribution pattern of Cr and UA concentration in urine samples obtained from suspected drug abusers (n=46). Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

7 Fig. 5 Urinary UA/Cr ratio measured by LC–MS/MS.
Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

8 Fig. 6 Comparison of urinary Cr and UA concentrations measured by cobas c 311 analyzer and LC–MS/MS. Forensic Science International  , 57-64DOI: ( /j.forsciint ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

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