Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 1. Chemical structures of aristolochic acid I (AAI) and II (AAII). From: Aristolochic acid as a probable human cancer hazard in herbal remedies:

Published byHugh Higgins Modified over 6 years ago

Similar presentations

Presentation on theme: "Fig. 1. Chemical structures of aristolochic acid I (AAI) and II (AAII). From: Aristolochic acid as a probable human cancer hazard in herbal remedies:"— Presentation transcript:

1 Fig. 1. Chemical structures of aristolochic acid I (AAI) and II (AAII).
From: Aristolochic acid as a probable human cancer hazard in herbal remedies: a review Mutagenesis. 2002;17(4): doi: /mutage/ Mutagenesis | © UK Environmental Mutagen Society/Oxford University Press 2002

2 Fig. 2. Metabolism of aristolochic acid I and II (from Krumbiegel et al., 1987).
From: Aristolochic acid as a probable human cancer hazard in herbal remedies: a review Mutagenesis. 2002;17(4): doi: /mutage/ Mutagenesis | © UK Environmental Mutagen Society/Oxford University Press 2002

3 Fig. 3. Metabolic activation and DNA adduct formation of aristolochic acid I (AAI, R = OCH<sub>3</sub>) and II (AAII, R = H); 7-(deoxyadenosin-N<sup>6</sup>-yl)aristolactam I or II (dA–AAI or dA–AAII), 7-(deoxyguanosin-N<sup>2</sup>-yl)aristolactam I or II (dG–AAI or dG–AAII). From: Aristolochic acid as a probable human cancer hazard in herbal remedies: a review Mutagenesis. 2002;17(4): doi: /mutage/ Mutagenesis | © UK Environmental Mutagen Society/Oxford University Press 2002

4 Fig. 4. Postulated mechanism for the carcinogenicity of aristolochic acid in rodents and humans. AAI, aristolochic acid I; dA–AAI, 7-(deoxyadenosin-N<sup>6</sup>-yl)aristolactam I; dA, deoxyadenosine. From: Aristolochic acid as a probable human cancer hazard in herbal remedies: a review Mutagenesis. 2002;17(4): doi: /mutage/ Mutagenesis | © UK Environmental Mutagen Society/Oxford University Press 2002

Download ppt "Fig. 1. Chemical structures of aristolochic acid I (AAI) and II (AAII). From: Aristolochic acid as a probable human cancer hazard in herbal remedies:"

Similar presentations

CH 11 RISK, TOXICOLOGY and HUMAN HEALTH 21.1 What is Risk? Probability that _______ A.Diff b/n risk assesment and risk managemnt 1.Risk assesment-__ 2.Risk.

CH 11 RISK, TOXICOLOGY and HUMAN HEALTH 21.1 What is Risk? Probability that _______ A.Diff b/n risk assesment and risk managemnt 1.Risk assesment-__ 2.Risk.
Genetic Mutations Frame-shift and point mutations.

Genetic Mutations Frame-shift and point mutations.
Is depleted uranium a carcinogen? Keith Baverstock PhD Department of Environmental Science University of Kuopio Finland.

Is depleted uranium a carcinogen? Keith Baverstock PhD Department of Environmental Science University of Kuopio Finland.
©Chaves, Hofelt, Shea. Environmental Toxicology and Chemistry Environmental Toxicology and Chemistry Intoxication Mechanisms II.

©Chaves, Hofelt, Shea. Environmental Toxicology and Chemistry Environmental Toxicology and Chemistry Intoxication Mechanisms II.
Curing HIV requires overcoming the virus’s ability to evolve There have been many attempts to cure HIV through as many different mechanisms. A common fail.

Curing HIV requires overcoming the virus’s ability to evolve There have been many attempts to cure HIV through as many different mechanisms. A common fail.
Terisse Brocato Miguel Pena Stephen Esquivel Victor Salgado.

Terisse Brocato Miguel Pena Stephen Esquivel Victor Salgado.
DNA Adduct Formation in Zebrafish Early Development and DNA Damage Eric Brooks Mentor: Dr. William Baird.

DNA Adduct Formation in Zebrafish Early Development and DNA Damage Eric Brooks Mentor: Dr. William Baird.
Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis.

Microbial Genetics (Micr340) Lecture 14 DNA Repair and Mutagenesis.
Figure 1.1 The observer in the truck sees the ball move in a vertical path when thrown upward. (b) The Earth observer views the path of the ball as a parabola.

Figure 1.1 The observer in the truck sees the ball move in a vertical path when thrown upward. (b) The Earth observer views the path of the ball as a parabola.
14.4 Gene Mutations. What is a Mutation? A mutation is any change in the amount or structure of the DNA of an organism. KEY POINT: If this occurs in somatic.

14.4 Gene Mutations. What is a Mutation? A mutation is any change in the amount or structure of the DNA of an organism. KEY POINT: If this occurs in somatic.
ILSI Risk Science Institute Acrylamide Toxicity: Research to Address Key Data Gaps Presented by Dr. Stephen S. Olin ILSI Risk Science Institute.

ILSI Risk Science Institute Acrylamide Toxicity: Research to Address Key Data Gaps Presented by Dr. Stephen S. Olin ILSI Risk Science Institute.
28/05/12 Questions (Rispondete alle domande che seguono usando il colore rosso per il testo) Tossicologia - Rubbiani Maristella.

28/05/12 Questions (Rispondete alle domande che seguono usando il colore rosso per il testo) Tossicologia - Rubbiani Maristella.
In meiosis, the nucleus divides to form 4 daughter nuclei. Meiosis allows for differences in inherited characteristics.

In meiosis, the nucleus divides to form 4 daughter nuclei. Meiosis allows for differences in inherited characteristics.
Key Concepts  Types of hazards people face  Methods of toxicology  Types and measurement of chemical hazards  Types and effects of biological hazards.

Key Concepts  Types of hazards people face  Methods of toxicology  Types and measurement of chemical hazards  Types and effects of biological hazards.
Companion PowerPoint slide set The Exposome: Investigating Vinyl Chloride and DNA Damage This teacher slide set was created by Dana Haine, MS, of the UNC-Chapel.

Companion PowerPoint slide set The Exposome: Investigating Vinyl Chloride and DNA Damage This teacher slide set was created by Dana Haine, MS, of the UNC-Chapel.
Safety Test Review GHSPICTOGRAMS GHS (Global Harmonization System) GHS pictogram labels are used to depict the recommended measures that should be taken.

Safety Test Review GHSPICTOGRAMS GHS (Global Harmonization System) GHS pictogram labels are used to depict the recommended measures that should be taken.
Lecture 10 – DNA Mutation Based on Chapter 07 Copyright © 2010 Pearson Education Inc.

Lecture 10 – DNA Mutation Based on Chapter 07 Copyright © 2010 Pearson Education Inc.
Juan Alguacil, MD Huelva University Brussels, 26 June 2012 Limits on Occupational Exposure Limits for Carcinogens 8th Seminar on workers’ protection &

Juan Alguacil, MD Huelva University Brussels, 26 June 2012 Limits on Occupational Exposure Limits for Carcinogens 8th Seminar on workers’ protection &
Renal Excretion of Aristolochic Acid I in the IPK

Renal Excretion of Aristolochic Acid I in the IPK
Mutations http://www.chemistryexplained.com/images/chfa_03_img0589.jpg.

Mutations

Similar presentations

Ads by Google