1. Immunomodulatory Activity and Effectiveness of Macrolides in Chronic Airway Disease 
Bruce K. Rubin, MEngr, MD, FCCP, Markus O. Henke, MD 
CHEST 
Volume 125, Issue 2, Pages 70S-78S (February 2004)
DOI: /chest.125.2_suppl.70S
Copyright © 2004 The American College of Chest Physicians Terms and Conditions

2. Figure 1
The survival rate of patients treated with erythromycin (group c EM+) was significantly greater than that of untreated patients (group c EM-) [p < ]. Untreated patients were not different from historical control subjects (group a) [p < ]. This figure was adapted with permission from Kudoh et al.2
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Copyright © 2004 The American College of Chest Physicians Terms and Conditions

3. Figure 2
Top, A: Mean FEV1 increased within 3 months of beginning clarithromycin therapy in 10 subjects with DPB. A maximal value was reached at 6 months and was sustained for 4 years. Bottom, B: The FVC increased to a maximal level within 6 months of beginning clarithromycin and was sustained for 4 years. * = p < 0.01 compared to baseline; ** = p < 0.05 compared to baseline; ## = p < compared to baseline. This figure was adapted with permission from Kadota et al.3
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Copyright © 2004 The American College of Chest Physicians Terms and Conditions

4. Figure 3
Left: The level of IL-8 (mean ± SE) in the BALF of subjects with DPB was compared before and after macrolide therapy, and was compared to subjects with sarcoidosis (SAR) or healthy volunteers. Right: Correlation between the percentage of neutrophils and the levels of IL-8 in the BALF of 19 subjects with DPB (r = 0.509; p < 0.05). This figure was adapted with permission from Sakito et al.31
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Copyright © 2004 The American College of Chest Physicians Terms and Conditions

5. Figure 4
Left, A: Mean (95% CI) change from baseline of FEV1 in 41 children with CF who were treated with azithromycin and placebo in a crossover trial. The mean FEV1 was greater during the azithromycin arm of the trial (p = 0.031). The median relative difference between azithromycin and placebo was 5.4% (95% CI, 0.8 to 10.5). Right, B: Mean (95% CI) change from baseline visit of FVC percent predicted for each treatment period. This figure was adapted with permission from Equi et al.44
CHEST  , 70S-78SDOI: ( /chest.125.2_suppl.70S)
Copyright © 2004 The American College of Chest Physicians Terms and Conditions