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Origins of anterior –posterior polarity in Drosophila Melanogaster

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Presentation on theme: "Origins of anterior –posterior polarity in Drosophila Melanogaster"— Presentation transcript:

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2 Origins of anterior –posterior polarity in Drosophila Melanogaster

3 Mid- blastula transition

4 in Drosophila (Part 1) DevBio9e-Fig-06-03-1R.jpg
Microtubules (green) microfilaments (blue) nuclei (red- Kugelkern protein) Nocadozole (microtubule block) DevBio9e-Fig R.jpg

5 Drosophila (Part 2) DevBio9e-Fig R.jpg

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8 oogenesis (Part 1) DevBio9e-Fig R.jpg

9 oogenesis (Part 2) DevBio9e-Fig R.jpg

10 oogenesis (Part 3) DevBio9e-Fig R.jpg

11 Comparison of larval and adult Drosophila

12 Bicoid (yellow) Hunchback (orange) Kruppel (green) Fushi Tarazu (Dark Blue) Nusslein Volhard and Wieschaus Nobel prize 1995 Engrailed (green)

13 Drosophila segmentation genes
Gap: Kruppel (Kr),knirps (kni), hunchback (hb), giant (gt),tailless tll), Pair rule: even skipped (eve),hairy (h), runt (run), fushi tarazu (ftz) Segment polarity: engrailed (en),wingless (wg),cubitus interuptus (ci),hedgehog (hh),armadillo (arm), patched (ptc) Homeotic genes: Antennapedia (Antp), Deformed (Dfd), Ultrabithorax (Ubx)

14 specification in Drosophila
DevBio9e-Fig jpg

15 Figure 6.21 Bicoid mRNA and protein gradients shown by in situ hybridization and confocal microscopy
DevBio9e-Fig jpg

16 DevBio9e-Fig R.jpg

17 DevBio9e-Fig R.jpg

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23 DevBio9e-Fig jpg

24 Ubx mutant fly

25 mutation DevBio9e-Fig jpg

26 Figure 6.2 Nuclear and cell division in Drosophila
DevBio9e-Fig jpg

27 (Part 2) DevBio9e-Fig R.jpg

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29 Drosophila DevBio9e-Fig jpg

30 Essay guidelines A) 5 pages excluding refs (text double spaced, references single spaced). Use 5-10 primary references from the literature Nature, Cell, Science, Genes and Development, Development, Developmental Biology, Mechanisms of Development, Developmental Cell. Attempt to synthesize and analyze the papers (try NOT to provide a catalogue) Use numbered referencing system in the text. Can use ONE diagram or data figure Due date: Thurs April 4th in class- hard copy

31 Drosophila gastrulation- molecular basis of A-P axis development
Gilbert Ch 6 The genetics of axis specification in Drosophila p or 9th Edition Fruit fly Drosophila melanogaster


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