1. Research Group Intestinal Microbiome
Thomas Clavel
TU München ZIEL Institute for Food and Health
Research Group Intestinal Microbiome
global & host-specific analysis
Ilias Lagkouvardos
Martin Kapfhammer
Divya Joseph
Sabahattin Giritli

2. Microbes are very important on earth!

3. Anaerobic cultivation

4. High-throughput 16S rRNA gene amplicon SEQUENCING

5. Make use of stored 16S sequencing data via IMNGS
Sequence Read Archive (SRA)
DB of 88,579 samples
Test ecological relevance of target bacteria
Study the diversity of specific bacterial taxa

7. In the future…

8. Literature
1. Lagkouvardos, Joseph, Kapfhammer, Giritli, Horn, Haller, Clavel (2016) IMNGS: A massive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies. Sci Rep 6:33721
2. Lagkouvardos, […] Overmann, Stecher, Clavel (2016) The mouse intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nature Microbiol 1:16131
3. Lee,* Clavel,* […] Haller (2016) Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with inflammatory bowel diseases. Gut, doi: /gutjnl
4. Clavel, Lagkouvardos, Hiergeist (2016) Microbiome sequencing: challenges and opportunities for molecular medicine. Expert Rev Mol Diagn 16:795
5. Lagkouvardos, […] Rohn, Skurk, Clavel (2015) Gut metabolites and bacterial community networks during a pilot intervention study with flaxseeds in healthy adult men. Mol Nutr Food Res 59:1614