1. Figure 2. Proposed phenotypes of type 2 DCs
Figure 2. Proposed phenotypes of type 2 DCs. Conventional DCs commonly express CD11c and MHC class II. Type 2 DCs exhibit the specialized surface markers CD301b, PDL2, and CD11b and several receptors for Th2 cell-related cytokines such as IL-4R, IL-13R, IL-25R, TSLPR, and T1/ST2 (IL-33R). Signaling through cytokine receptors upregulates the expression of PDL2 and CD301b. Additionally, the ERK and STAT5 pathway upregulates CD40, OX40L, and Jagged. Activation of the major transcription factors IRF4 and KLF4 inhibits IL-12 production and increases IL-10 secretion. FcεRIII displayed by type 2 DCs is responsible for inducing IgG1-related Th2 responses. Altogether, these factors trigger Th2 polarization.
Figure 2. Proposed phenotypes of type 2 DCs. Conventional DCs commonly express CD11c and MHC class II. Type 2 DCs exhibit the specialized surface markers CD301b, PDL2, and CD11b and several receptors for Th2 cell-related cytokines such as IL-4R, IL-13R, IL-25R, TSLPR, and T1/ST2 (IL-33R). Signaling through cytokine receptors upregulates the expression of PDL2. . .
Immune Netw Feb;16(1):