1. Affect of DNA-PK on Foci Persistence
J. Dickey

2. J Cell Controls (0 Gy)
0 hr
48 hr
24 hr
72 hr

3. K Cell Controls (0 Gy)
0 hr
48 hr
24 hr
72 hr

4. J Cells 3 Gy
0.5 hr
1 hr
3 hr
6 hr
10 hr
24 hr
48 hr
72 hr

5. K Cells 3 Gy
0.5 hr
1 hr
3 hr
6 hr
10 hr
24 hr
48 hr
72 hr

6. J Cells 5 Gy
0.5 hr
1 hr
3 hr
6 hr
10 hr
24 hr
48 hr
72 hr

7. K Cells 5 Gy
0.5 hr
1 hr
3 hr
6 hr
10 hr
24 hr
48 hr
72 hr

8. J vs. K cells 10 hr post 3 Gy IR
J Cells
K Cells

9. J vs. K cells 10 hr post 5 Gy IR
J Cells
K Cells

10. Conclusions
J cells (deficient in DNA-PK expression) have greater foci persistence over time after IR.
Overall numbers of foci between J cells and K cells at 30 min post-IR seem similar.
DNA-PK seems to play a role in foci removal.