1. HPLC of intact underivatized bilirubin tetrapyrroles in human bile from a normal individual (A) and from patients with Crigler-Najjar syndrome type I (B), Crigler-Najjar syndrome type II (Arias syndrome) (C), Gilbert syndrome (D), and Dubin-Johnson syndrome (E). Bile pigments were separated by reverse-phase chromatography. Absorbance at 436 nm (ordinate) and retention time (abscissa) are shown. Peaks are as follows: 1, bilirubin diglucuronide; 2, bilirubin glucoside-glucuronide mixed conjugate; 3 and 4, C-8 and C-12 isomers of bilirubin monoglucuronide; 5, unconjugated bilirubin.
Source: Hereditary Jaundice and Disorders of Bilirubin Metabolism, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 09, 2017
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