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Quantitative Blush Evaluator accurately quantifies microvascular dysfunction in patients with ST-elevation myocardial infarction: Comparison with cardiovascular.

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Presentation on theme: "Quantitative Blush Evaluator accurately quantifies microvascular dysfunction in patients with ST-elevation myocardial infarction: Comparison with cardiovascular."— Presentation transcript:

1 Quantitative Blush Evaluator accurately quantifies microvascular dysfunction in patients with ST-elevation myocardial infarction: Comparison with cardiovascular magnetic resonance  Italo Porto, MD, PhD, Christian Hamilton-Craig, MBBS, FRACP, Giovanni Luigi De Maria, MD, Rocco Vergallo, MD, Giorgio Cautilli, MD, Leonarda Galiuto, MD, PhD, FACC, Francesco Burzotta, MD, PhD, Antonio Maria Leone, MD, PhD, Giampaolo Niccoli, MD, PhD, Luigi Natale, MD, Lorenzo Bonomo, MD, Filippo Crea, MD, FESC, FACC  American Heart Journal  Volume 162, Issue 2, Pages e2 (August 2011) DOI: /j.ahj Copyright © 2011 Mosby, Inc. Terms and Conditions

2 Figure 1 Flow chart of patients included in the QuBE and CMR analysis.
American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

3 Figure 2 Relations between the QuBE value and total ischemic time and ΣSTR. The box represents 25° and 75% percentiles (IQR); straight line, median; and whiskers, 1.5 IQR. American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

4 Figure 3 Scatter plots reporting the inverse relationship between the QuBE values and IS and DE-MVO. American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

5 Figure 4 Scatter plots reporting the relationship between the QuBE values and FP-MVO, MSI, TnT peak, and intramyocardial hemorrhage. American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

6 Figure 5 Receiver operating characteristic curves for sensitivity and specificity of QuBE in detecting DE-MVO, FP-MVO, and hemorrhage. American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

7 Supplementary Figure 1 Screenshot of a coronary angiogram with example of the use of Quantitative Blush Evaluator (QuBE) software. A region of interest is manually drawn over the myocardium perfused by the infarct-related-artery (left panel), and a perfusion curve is generated (right panel). The curve represents the quantified value in all frames and the QuBE value equals the maximum increase (from frame 21 to frame 54) plus the maximum decrease (from frame 54 to frame 100). American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions

8 Supplementary Figure 2 Quantification of Delayed Enhancement-MicroVascular Obstruction (DE-MVO). Short axis basal slice delayed enhancement image (left) demonstrating a large full thickness anteroseptal infarct with inferior wall involvement, and multiple zones of DE-MVO. Planimetry of endocardial and epicardial borders (right, white lines) and zones of DE-MVO (yellow lines) allow calculation of the volume of DE-MVO, expressed in grams and as percentage of myocardial mass. American Heart Journal  , e2DOI: ( /j.ahj ) Copyright © 2011 Mosby, Inc. Terms and Conditions


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