1. The Hypotensive Effect of L-Arginine Is Associated With Increased Expired Nitric Oxide in Humans 
Sanjay Mehta, MD, Duncan J. Stewart, MD, Robert D. Levy, MD, FCCP 
CHEST 
Volume 109, Issue 6, Pages (June 1996)
DOI: /chest
Copyright © 1996 The American College of Chest Physicians Terms and Conditions

2. FIGURE 1
Time course of changes in mean BP, expired NO (VeNO), and plasma L-citrulline during infusion of hypertonic saline solution and L-arginine. Although the hypertonic saline solution control (open circles) had no effect, a 30-min infusion of L-arginine (filled circles) was associated with a reduction in mean BP and increases in expired NO and plasma L-citrulline. L-arginine's effects were transient, as all parameters returned to baseline during the recovery period. Asterisk=p<0.05 by repeated measures ANOVA and Student's t test.
CHEST  , DOI: ( /chest )
Copyright © 1996 The American College of Chest Physicians Terms and Conditions

3. FIGURE 2
The peak effects of hypertonic saline (SAL) solution and L-arginine (ARG) on mean BP, plasma L-citrulline, and expired NO in individual subjects (n=10). L-arginine infusion reduced mean BP and increased plasma L-citrulline and expired NO in all subjects, with the peak effects being observed at 32±7, 59±4, and between 60 and 75 min, respectively, after start of the infusion. Both the FeNO and the VeNO increased following L-arginine administration. In contrast, the hypertonic saline solution control had no consistent hemodynamic or metabolic effects. Asterisk=p<0.05 by repeated measures ANOVA.
CHEST  , DOI: ( /chest )
Copyright © 1996 The American College of Chest Physicians Terms and Conditions