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Antibiotic Treatment of Exacerbations of COPD

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1 Antibiotic Treatment of Exacerbations of COPD
Stolz Daiana , MD, Christ-Crain Mirjam , MD, Bingisser Roland , MD, Leuppi Jörg , MD, Miedinger David , MD, Müller Christian , MD, Huber Peter , PhD, Müller Beat , MD, Tamm Michael , MD  CHEST  Volume 131, Issue 1, Pages 9-19 (January 2007) DOI: /chest Copyright © 2007 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Trial profile. ECOPD = exacerbation of chronic obstructive lung disease; CHF = cardiac heart failure; URTI = upper respiratory tract infection; GOLD = Global Initiative for Chronic Obstructive Lung Disease. CHEST  , 9-19DOI: ( /chest ) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Distribution of procalcitonin levels on admission in 102 patients in the procalcitonin-guided group and 106 patients in the standard-therapy group. CHEST  , 9-19DOI: ( /chest ) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Total number of antibiotic courses at short-term and long-term follow-up in 102 patients in the procalcitonin-guided group and 106 patients in the standard-therapy group. CHEST  , 9-19DOI: ( /chest ) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Top,A: Kaplan-Meier estimates of the probability of remaining relapse-free and alive at 6 months in the procalcitonin-guided group (n = 102) and standard-therapy group (n = 106).Bottom,B: Kaplan-Meier estimates of the probability of remaining free of a relapse of COPD requiring hospitalization and alive at 6 months in the procalcitonin-guided group (n = 102) and standard-therapy group (n = 106). CHEST  , 9-19DOI: ( /chest ) Copyright © 2007 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Top,A: change in FEV1in patients who have not been treated with antibiotics during the index exacerbation in the procalcitonin-guided group (n = 61) and standard-therapy group (n = 30). p Values compare the change in FEV1over time between both groups.Bottom,B: change in FEV1in patients who have been treated with antibiotics during the index exacerbation in the procalcitonin-guided group (n = 41) and standard-therapy group (n = 76). p Values compare the change in FEV1over time between both groups. CHEST  , 9-19DOI: ( /chest ) Copyright © 2007 The American College of Chest Physicians Terms and Conditions


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