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Human Varicella-Zoster Immune Globulin

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Presentation on theme: "Human Varicella-Zoster Immune Globulin"— Presentation transcript:

1 Human Varicella-Zoster Immune Globulin

2 Description : Indication:
Human Varicella-Zoster Immune Globulin is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV). Indication: Indicated for reducing the severity of chicken pox (varicella zoster virus) infections in high risk individuals after exposure

3 Pharmacodynamics : Provides passive immunization for non immune individuals exposed to varicella zoster virus, thereby reducing the severity of varicella infections.

4 Categories : Brands : VARIZIG
Antibody Brands : VARIZIG Description : VARIZIG [Varicella Zoster Immune Globulin (Human)] is a solvent/detergent-treated sterile liquid preparation of purified human immune globulin G (IgG) containing antibodies to varicella zoster virus (anti-VZV). VZV is the causative agent of chickenpox. VARIZIG is prepared from plasma donated by healthy, screened donors with high titers of antibodies to VZV, which is purified by an anion-exchange column chromatography manufacturing method.

5 Route of administration : Intramuscular administration
Dosage : Depending on patient size, divide the IM dose and administer in 2 or more injection sites; not to exceed 3 mL/injection site.

6 Contraindication : Hypersensitivity to human immunoglobulins
Contraindication : Hypersensitivity to human immunoglobulins. Side effects : The most common adverse drug reactions (reported by ≥ 1% of subjects) observed in clinical trials for all subjects and patients (n=601) are the following: injection site pain (3%),headache (2%),rash (including terms pruritus, rash, rash erythematous, rash vesicular and urticaria) (1%),fatigue (1%),chills (1%),nausea (1%).

7 References :


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