1. Normal platelet function
Normal platelet function. Important elements in platelet adhesion and aggregation include platelet shape change; adhesion to subendothelial collagen; aggregation of activated platelets; and release of ADP, thromboxane A2 (TxA2), platelet factor 4 (PF4), and β-thromboglobulin (βTG) to stimulate further platelet activation and recruit additional platelets into the aggregate. Thrombin acts as the most potent physiologic platelet activator to accelerate the process. von Willebrand factor bound to subendothelial collagen is essential for platelet adhesion via the GPIb receptor, whereas fibrinogen is the essential cofactor in the GPIIb/IIIa-mediated platelet-platelet aggregation process.
Source: PLATELET DYSFUNCTION AND VON WILLEBRAND DISEASE, Hematology in Clinical Practice, 5e
Citation: Hillman RS, Ault KA, Leporrier M, Rinder HM. Hematology in Clinical Practice, 5e; 2016 Available at: Accessed: November 09, 2017
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