1. DISORDERS OF THE KIDNEY AND URINARY TRACT
By Alireza Hosseini, M.D
Occupational medicine specialist

2. Kidney poisoning 20% of cardiac output GFR =180 l/d
Reabsorbtion of elements

3. CLINICAL EVALUATION Symptoms and signs of acute poisoning
Symptoms and signs of chronic poisoning

4. Laboratory testing
GFR CALCULATION
BUN , Cr
U/A
Urine proteins

5. Urine proteins High molecular weight plasma proteins
as alb ,transferrin
Low molecular weight plasma proteins
as RBP, ᵦ2M
glycoproteins of renal origin
as NAG,HIAP

6. Urine proteins Glomerular damage : excessive HMW pr
Proximal tubular damage : both HMW & LMW but markedly LMW

7. Urine proteins 40% :High molecular weight plasma proteins
20% : Low molecular weight plasma proteins
40% : glycoproteins of renal origin

8. DISORDERS OF THE KIDNEY AND URINARY TRACT
Acute renal disorders
Pigment nephropathy
Acute tubulointerstitial nephritis
Acute toxic glomerulonephropathy
Chronic renal disorders
Chronic tubulointerstitial nephropathy
Chronic glomerulonephropathy
Vascular nephropathy
Renal papillary necrosis
Renal cystic disease
Radiation nephritis
Hypertension
Non-renal urinary tract disorders
Urolithiasis
Bladder disorders

9. Pigment nephropathy
Rhabdomyolysis
Hemolysis
methemoglobinemia

10. Acute tubulointerstitial nephritis
Heavy metals
Organic solvents
Halogenated hydrocarbons
Ccl4
Chloroform
Petroleum distillants
turpentine
gasoline
toluene
Arsenic
Cadmium
Chromium
Lead
Mercury
Silver
uranium

11. Acute toxic glomerulonephropathy
Mercury
Silica
Mixtures of organic solvents

12. Chronic tubulointerstitial nephropathy
Cadmium
beryllium
Lead
Mercury

13. Chronic glomerulonephropathy
Mercury
Silica
Organic solvents

14. Vascular nephropathy
Carbon disulfide

15. Renal papillary necrosis
Experimentary induced by diphenylamine , dioxin,PCBs

16. Renal cystic disease
Experimentary induced by diphenylamine & diphenylthiazole;…

17. Hypertension
Lead
Possibly cademium
Carbon disulfide

18. Urolithiasis Chronic Cadmium exposure,up to 44% of exposed workers
Chronic beryllium exposure

19. Bladder disorders
Neurogenic bladder by DMAPN

20. THANKS FOR YOUR ATTENTION