1. Correlation Between Five Exercise Tests to the COPD Assessment Test (CAT) in Stable Chronic Obstructive Pulmonary Disease (COPD)
Harvey-Dunstan TC1,2, Edwards SE1, Houchen-Wolloff L1, Tal-Singer R3, Polkey MI4, Morgan MD1,2, Steiner MC1,5, Singh SJ1,5
1Centre for Exercise & Rehabilitation Science, Glenfield Hospital, Leicester, UK; 2University of Leicester, UK;
3GSK R&D, King of Prussia, PA USA;, 4Royal Brompton & Harefield NHS Foundation Trust, London, UK; 5Loughborough University, UK.
hen-Wolloff L1, Tal-Singer R3,olkey MI4,
Morgan MD1,2, Steiner MC1,5, Singh SJ1,5
1Centre for Exercise & Rehabilitation Science, Glenfield Hospital, Leicester, UK; 2University of Leicester, UK;
3GSK R&D, King of Prussia, PA USA;, 4Royal Brompton & Harefield NHS Foundation Trust, London, UK; 5Loughborough University, UK.
Background
Evidence suggests that a relationship exists between exercise capacity and the COPD Assessment Test. There is however no concurrent comparison of the correlations between the most commonly employed exercise tests and the CAT score.
Aim: To compare the correlation between the CAT score and Incremental Cycle Ergometry (ICE), Constant Work Rate Cycle Test (CWR), Incremental Shuttle Walk Test (ISWT), Endurance Shuttle Walk Test (ESWT) and the Six Minute Walk Test (6MWT) in patients with stable COPD.
Results
46 subjects (mean [SD] or *median (IQR); age (years) [7.9], %male 80.4, MRC* 3 [3-3], FEV1 % Predicated [17.78], ISWT (m) 307 [0.39], ESWT (sec) [236.54], 6MWT (m) [83.40], ICE WRPEAK (w) [27.16], CWR tlim (sec) [102.54]) were included.
Significant correlations were seen between the CAT and the ISWT (r=0.50 P<0.01), 6MWT (r=0.53 P<0.01) and ICE (r=0.45 p<0.01) See Figure 1; A, B and C.
No significant correlations were observed for the ESWT (r=0.08) or CWR (r=0.17) See Figure 1; D and E.
Figure 1: Correlations between the CAT Score and A) ICE WRPEAK B) ISWT C) 6MWT D) CWR tlim E) ESWT A B
Methods
46 patients with symptomatic COPD (MRC>3, GOLD Stage>2) were recruited to a larger randomised controlled trial (ISRCTN: ).
Following familiarisation subjects performed a symptom- limited test for the following:
Data was analysed using appropriate parametric and non- parametric testing and reported as mean[SD} or *median [IQR]. C
Table 1: Demographics
n=46
Age (Years)
65.5 [7.9]
Gender (% Male)
80.4%
Smoking (% Current)
26.1%
Pack Years (Years)
47.9 [37.2]
MRC*
3 [3-3]
BMI (Kmm-2)
27.9 [6.3]
Pulmonary Function
FEV1 % Predicted
48.22 [17.78]
FEV/FVC
43.39 [13.60]
TLCO
5.34 [1.73]
Co-Morbidities
Total Number*
2 [0.75-3]
ICE, CWR, ISWT, ESWT, 6MWT
CAT
Familiarisation
ICE, ISWT, 6MWT
CWR, ESWT
Baseline D E
mean [SD] or *median [IQR]
Conclusion
A significant relationship was observed between the CAT Score and the ISWT, 6MWT and ICE. No significant correlation was observed with the endurance protocols.