1. Tyler Dorrity Dr. DasMahapatra
Cancer Immunotherapy
Tyler Dorrity
Dr. DasMahapatra

2. Types of Immunity: Innate
Nonspecific
Physical and chemical barriers
Inflammation
PRR’s and PAMP’s
Cytokines and pyroptosis
Complement System

3. Types of Immunity: Innate
Nonspecific
Physical and chemical barriers
Inflammation
PRR’s and PAMP’s
Cytokines and pyroptosis
Complement System

4. Types of Immunity: Innate
Nonspecific
Physical and chemical barriers
Inflammation
PRR’s and PAMP’s
Cytokines and pyroptosis
Complement System

5. Types of Immunity: Innate
Leukocytes
Chemotaxis (Interleukin) and Phagocytosis
Dendritic Cells
Neutrophils (NETs and cytokines)
Macrophages (M1, M2 and arginine)
NK Cells
“Self”, “Non-Self”, and “Missing Self” Cells
MHC 1 and 2 Markers

6. Types of Immunity: Innate
Leukocytes
Chemotaxis (Interleukin) and Phagocytosis
Dendritic Cells
Neutrophils (NETs and cytokines)
Macrophages (M1, M2 and arginine)
NK Cells
“Self”, “Non-Self”, and “Missing Self” Cells
MHC 1 and 2 Markers

7. Types of Immunity: Adaptive
Specific (Vertebrates only)
Lymphocytes
B Cells
Memory and Plasma
T Cells
Helper and Memory
Cytotoxic and NKT

8. Types of Immunity: Adaptive
Specific (Vertebrates only)
Lymphocytes
B Cells
Memory and Plasma
T Cells
Helper and Memory
Cytotoxic and NKT

9. Types of Immunity: Adaptive
Specific (Vertebrates only)
Lymphocytes
B Cells
Memory and Plasma
T Cells
Helper and Memory
Cytotoxic and NKT

10. How does this relate to cancer treatments?

12. Types of Cancer Immunotherapy
Cytokine Therapy
Dendritic Cell Vaccines
In or ex vivo
Targeted Therapies
Monoclonal Antibodies (MAb)

13. Types of Cancer Immunotherapy
Cytokine Therapy
Dendritic Cell Vaccines
In or ex vivo
Targeted Therapies
Monoclonal Antibodies (MAb)

14. Types of Cancer Immunotherapy
Cytokine Therapy
Dendritic Cell Vaccines
In or ex vivo
Targeted Therapies
Monoclonal Antibodies (MAb)

16. Immune Checkpoints PD-L1 Pathway Slows immune propagation
Interference with PD-L2

17. Immune Checkpoints PD-L1 Pathway Slows immune propagation
Interference with PD-L2

18. Immune Checkpoints PD-L1 Pathway Slows immune propagation
Interference with PD-L2

19. Thank You
Any questions?