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eczema
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Definition Pruritic papulovesicular dermatitis characterised by erythema, oedema and a serous exudate in the epidermis.
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Pathophysiology Two hypotheses:
1) Immunological disturbance causes IgE-mediated sensitisation, epithelial barrier dysfunction is secondary (Endogenous Eczema) 2) Epidermal barrier dysfunction allows irritants and allergens into the skin, with immunological disturbance secondary (Exogenous Eczema)
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classified by pathophysiology
Contact dermatitis Housewives hand eczema Keratodermia tylodes palamaris progressiva(Hand eczema) Diaper dermatitis Atopic dermatitis Seborrheic dermatitis Nummular eczema Lichen simplex chronicus Lichen Vidal autosensitisation dermatitis Stasis dermatitis
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causes Allergy Genetics Abnormal function of the immune system Environment Activities that may cause skin to be more sensitive
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Staging of eczema Acute eczema Subacute eczema Chronic eczema
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1- Acute eczema It is accompanied by exocytosis of lymphocytes and spongiotic bulla, It is newly produced eczema only several days after its onset
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clinical feature Exudative erythema Oedema Vesicles (sometimes) Intercellular oedema (spongiosis), intense dermal oedema, and inflammation occur. Acanthosis usually does not
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Skin care: moisturizing the skin AND avoid irritant.
treatment Education! Skin care: moisturizing the skin AND avoid irritant. Topical corticosteroids.
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2- Subacute eczema Subacute eczema has a severity between that of acute and that of chronic
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clinical feature Erythema Oedema, and it is slightly lichenoid. Mild oedema is produced in the epidermis. Acanthosis Parakeratosis are observed
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3- Chronic eczema Hyperkeratosis Parakeratosis Irregular acanthosis, and elongation of rete ridges are observed. Spongiosis and spongiotic bulla are less severe in chronic eczema than in acute eczema more than one week after onset
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clinical feature Lichenification Dry, sensitive skin
Red, inflamed skin Scaly areas Recurring rash Rough, leathery patches Swelling Dark-colored patches of skin
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treatment Choose the correct steroid for the site and activity of disease. Remove the causative agents if it is contact dermatitis. Treat the dryness (Emollients). Use keratolytics if it is seborrhoeic eczema. Antihistamines (Itching).
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