1. Anti-aging effects: caloric restriction FMUC 2009/2010 BCM
Carolina Soares
Catarina Lopes
Catarina Patronillo
Cláudia Costa

2. Caloric Restriction
= Longevity Diet?

3. What is it?
CR consists in eating fewer calories (25% less) and maintaining adequate nutrition.
Eating less is not enough, it will lead you to malnutrition.
You must eat adequate vitamins, minerals and other essential nutrients.

4. Mechanisms of function:
Mito(hormesis);
Insulin signalling - autopahgy;
Oxidative stress – free radicals

5. + 50% Less common disorders: • Cancer; • Diabetes;
• Cardiovascular disorders;
• Cerebral atrophy
• with caloric restriction;
• without caloric restriction;
These results were seen only in animals, what causes some controversy in what concerns to humans!
+ 50%

6. IMC Caloric Restriction Positive effects on: • cholesterol levels;
• blood pressure
IMC

7. How caloric restriction has anti aging effects?
oxidative stress
Insulin
radicals
Autophagy
How caloric restriction has anti aging effects?
O .
O .
O .
O .
O .
O .
O .
O .
O .
O .
O .
O .
O . O2

8. • Reduce the risk of chronic diseases
Benefits
• Reduce the risk of chronic diseases
• Improve memory
• Parkinson
• Alzheimer

9. CR’s Risks Hunger, cravings or food obsession Reduced energy reserves
Decreased of bone health
Loss of strenght
Menstrual irregularity
Cold sensitivity

10. Excessive food thoughts and fantasies
Psychological disturbances
Anorexia
Binging
Excessive food thoughts and fantasies

11. Perturbation of family meals; Lose much time preparing meals.
Familiar changes
Perturbation of family meals;
Lose much time preparing meals.
Social changes

12. CR vs Anorexia Differences: CR Anorexia
The motivations are longevity and health
The motivation is the image
Good nutrition
Bad nutrition
Feeling good with themselves
Never satisfied with the way they look
Public
Hidden
Focus are calories
Focus is the weigh

13. Similarities: Slowed metabolism; Loss of weight : Loss of muscle mass;
Menstrual irregularity (and in some cases amonherrea) - in women;
Decrease of testosterone levels – in men;
Loss of bone mass;
Cold sensitivity

14. Bibliography