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Ph-stat versus alpha-stat perfusion strategy during experimental hypothermic circulatory arrest: a microdialysis study  Matti Pokela, MD, Sebastian Dahlbacka,

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Presentation on theme: "Ph-stat versus alpha-stat perfusion strategy during experimental hypothermic circulatory arrest: a microdialysis study  Matti Pokela, MD, Sebastian Dahlbacka,"— Presentation transcript:

1 Ph-stat versus alpha-stat perfusion strategy during experimental hypothermic circulatory arrest: a microdialysis study  Matti Pokela, MD, Sebastian Dahlbacka, MS, Fausto Biancari, MD, PhD, Vilho Vainionpää, MD, PhD, Timo Salomäki, MD, PhD, Kai Kiviluoma, MD, PhD, Erkka Rönkä, MS, Timo Kaakinen, MS, Janne Heikkinen, MS, Jorma Hirvonen, MD, PhD, Pekka Romsi, MD, Vesa Anttila, MD, PhD, Tatu Juvonen, MD, PhD  The Annals of Thoracic Surgery  Volume 76, Issue 4, Pages (October 2003) DOI: /S (03)

2 Fig 1 Porcine model of hypothermic circulatory arrest. (a) Microdialysis catheter. (b) Epidural temperature probe. (c) Intracranial pressure monitoring catheter. (d) Intracerebral temperature probe. (e) Brain tissue oxygen monitoring catheter. (f) Electroencephalographic monitoring electrodes. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

3 Fig 2 Brain temperatures in pigs during the experimental protocol. Values are expressed as medians with interquartile ranges (25th to 75th percentile). *p less than 0.05, difference between study groups at a certain interval. (HCA = hypothermic circulatory arrest.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

4 Fig 3 (a) Mixed venous blood lactate, (b) cardiac index, (c) mean arterial pressure, and (d) vascular resistance. Values are expressed as the median with interquartile ranges (25th and 75th percentiles). *p less than 0.05, difference between study groups at a certain interval. The Annals of Thoracic Surgery  , DOI: ( /S (03) )

5 Fig 4 Results of brain microdialysis and brain tissue O2 partial pressure measurements (index to baseline). Values are expressed as medians with interquartile ranges (25th to 75th percentile). *p less than 0.05, difference between study groups are for particular interval. **p less than 0.01, difference between study groups at a certain interval. (HCA = hypothermic circulatory arrest.) (perf = perfusion.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

6 Fig 5 Results of brain microdialysis lactate-glucose ratio (right) and lactate-pyruvate ratio (center), and intracranial pressure values (left). Values are expressed as medians with interquartile ranges (25th and 75th). *p less than 0.05, difference between study groups at a certain interval. **p less than 0.01, difference between study groups at a certain interval. (HCA = hypothermic circulatory arrest.) The Annals of Thoracic Surgery  , DOI: ( /S (03) )

7 Fig 6 Daily score indicating behavioral recovery after 75 minutes of hypothermic circulatory arrest. A score of 9 indicates essentially complete recovery. (a) pH-stat group. (b) Alpha-stat group. The Annals of Thoracic Surgery  , DOI: ( /S (03) )


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