1. Center for Childhood Obesity Prevention
Monthly Training Meeting
Mentor-Mentee Development Plan
October 4, 2017
CARE Conference Room
Brandon Building – 2nd Floor
Arkansas Children’s Hospital
Center for Childhood Obesity Prevention

2. Overview of Agenda General Updates
Work-in-Progress Meeting on November 1
Quarterly Reporting
Mentor-Mentee Development Plan

3. General Updates CCOP Leadership had retreat on September 15
Investigator Project Status
Monthly Trainings
Pilot Study RFA
Core Functions and Personnel
EAC Meeting
Open House
Senior Mentoring

4. General Updates - Investigators
Primary
Mike Thomsen, PhD
-Training in agent based modeling with Dr. Bruce Lee at Johns Hopkins Global Obesity Prevention Center
-R01 target date: June or Oct. 2018
Eugenia Carvalho, PhD
-Revised IRB approved; starting subject recruitment
-R01 target date: Oct. 2019

5. General Updates - Investigators
Primary
Jamie Baum, PhD
-Submitting revised IRB per NICE review and reliance agreement between UAMS & UARK
-R01 target date: Oct. 2019
Pilot
Emir Tas, MD
-Waiting for approval on revised study design; resubmit IRB?
-Target start date: Nov. 2017

6. General Updates - Investigators
Pilot
Eva Diaz, MD
-Started subject recruitment
-Target completion date: Oct. 2018
Support Core
Mallik Rettiganti, PhD
-Will begin working on writing the code for detecting outliers as soon as ACHI mock data is received; should be this week
-Target start date: Oct. 2017

7. General Updates - Investigators
Affiliated
Chris Long, PhD
-Submitted revised proposal and budget based on suggestions from Dr Gittelsohn; Revised documents are under review.
-Target start date: Nov. 2017
Jon Oden, MD
-IRB under expedited review
Shannon Rose, PhD
- Started subject recruitment in tandem with Eugenia

8. General Updates – Monthly Trainings
New format starting January 2018
Proposed quarterly rotation for CCOP:
-WIP; remains in person only; open to all faculty
-Training topic that is CCOP focused only or external speaker in content areas of CCOP investigators
-Shared training session with other COBREs/KL2s

9. General Updates – Monthly Trainings
Share trainings with other COBREs and TRI KL2 program on general topics, such as:
Grant writing
CV/Biosketch development
Creating and Managing Budgets
IRB, IACUC, CT.gov and Institutional Compliance

10. General Updates – Pilot Study RFA for 2018
Letter of Intent (LOI)
Leadership Team Review
If Invited, Full Proposal Submission
Internal Advisory Committee (IAC) Review of Full Proposal
Revisions Based on IAC Review
Proposal Presentation to External Advisory Committee (EAC)
If Approved, Submission to NIGMS for Pilot Study Funding
RFA Program Process

11. General Updates – Pilot Study RFA for 2018
RFA Timeline
Friday, October 13 – Friday, December 1, 2017
Letter of Intent (LOI) Solicitation; LOI due by 5 pm on December 1
December 1 – 15, 2017
Leadership Team review of LOIs
Tuesday, January 16, 2018
Notify investigators of whether or not they are invited to submit a full proposal application
Friday, March 30, 2018
Full proposal applications due by 5 pm

12. General Updates – Pilot Study RFA for 2018
RFA Timeline
April 2018
IAC review and scoring of full proposal applications
Tuesday, May 15, 2018
IAC recommendation/next step decision letters sent to investigators
Friday, June 15, 2018
Revised applications due by 5 pm
Wednesday, July 11, 2018
Selected investigators to practice presentation for EAC Summer meeting at WIP meeting
August/September 2018 TBD
Selected investigators to present proposals to EAC at EAC Summer Meeting

13. General Updates – Core Functions and Personnel
Discussed potential need for establishing Center specific:
Data Safety and Monitoring Board
Community Advisory Board
Discussed potential need for additional support personnel for:
Clinics or user groups, e.g. biostats “chat” groups on design, analysis issues, etc specific to projects at any stage
Adding “coaches” for specific tasks, e.g. grant development components, manuscript writing, etc.

14. General Updates – EAC Meetings in 2018
Winter Meeting: February 6-7, 2018
Investigator project update presentations
EAC to review all junior investigator biosketches and CVs
EAC member research presentations; open to public
Participate in planning of research forum for the August/September Summer EAC Meeting

15. General Updates – EAC Meetings in 2018
Summer Meeting: TBD August/September 2018
Investigator project update presentations
Research forum
-Mentor research presentations
-External invited speakers
-Networking opportunities

16. General Updates – Open House
Open House for CCOP
November 27, 10:00 am – 12:00 pm
Brandon (South Campus) second floor, south end of hall
Display posters of each core and investigator projects
“Meet & Greet” format
Healthy refreshments

18. General Updates – Senior Mentoring
Senior Mentor Workshop on November 8 (all day)
Conducted by Drs. Mary Aitken and Beatrice Boateng (trained through the University of Wisconsin CTSA)
Refresher on desirable mentoring skills and responsibilities
Review & refresh specific roles & responsibilities of CCOP senior mentors
Are some roles more for external consultants & vice versa?

19. General Updates – Senior Mentoring
Review what CCOP mentees want, need from their mentors and consultants
Review what mentors expect of mentees
Discuss plans for improvement, re-booting

20. Next WIP Meeting Wednesday, November 1, 12:00 pm – 4:00 pm
Mandatory in-person for funded investigators; video- conferencing not available
Change in format:
-No formal presentations

21. WIP Meeting -Networking opportunities
-Discussion format – be prepared to share/discuss:
Start up delays; other delays
Methodological issues
Mentoring/or support issues
General progress
Timeline
-Networking opportunities

22. Quarterly Reporting Schedule
Due Date
Q1 Aug - Oct 2017
* reminder will be sent on October 16
November 1, 2017
Q2 Nov – Jan 2018
* reminder will be sent on January 15
February 1, 2018
Q3 Feb – Apr 2018
* reminder will be sent on April 16
May 1, 2018
Q4 May – Jul 2018
* reminder will be sent on July 16
August 1, 2018

23. Quarterly Reporting Issues
In Mentoring Report, under Summarize Recent Activity:
Provide authors, title, target journal, target date for in preparation or submitted paper
In Mentoring Report, under Summary of New Goals and Issues:
Limit goals to specific actionable items for the next quarter only
Don’t be too broad (e.g. repeating specific aims), but provide enough information to track progress.
Don’t be too vague (e.g. something like “start recruitment” is not enough)

24. Examples
List all goals the mentee should be working on during the next quarter:
Complete testing code in mock data set and begin testing code in real dataset.
Identify all three additional clinician raters and establish agreements (MOUs) with them as necessary.
Initiate subject recruitment (e.g. who, how) to meet target goal of X% or X number by X date.

25. Quarterly Reporting Issues
In Mentoring Report, under Recommendations:
Please indicate for each goal if it has been met or not met (or partially met) and describe progress of each. Can’t just say “our goals were met”.

26. Example
Instructions: Recommendations from the previous quarter and goals. For each goal, indicate if met or not met. If not met, describe progress, issues, and potential solutions.

27. Example
Response: The EAC (after the meeting in June) has made these five recommendations.
Recommend collaboration with Dr. Mike Thomsen (a Center Primary Investigator).
MET: I have contacted Dr. Mike Thomsen to get a access to a copy of the mock data. This will help to test the code and iron out major issues before executing code on the real data.

28. Example
David Allison (former External Advisory Committee member) will continue to provide guidance to this specific project.
MET: We have had a phone conversation with Dr. David Allison who has given some input and guidance related to this project. We will continue to consult with Dr. Allison as and when necessary.

29. Example
How generalizable is your software or can it be generalized to other types of data?
Not MET: The macro that we intend to create is expected to be used with height and weight z-scores in a similar setting. This is because the 'gold-standard' that we expect to obtain on a sample of patients using clinician raters will help us flag outliers by choosing an appropriate threshold.

30. Example
Without a gold standard, it is hard for the program to flag outliers since we do not know where the threshold lies. It is quite possible we will have the macro to flag the top 1% or 0.5% of values identified as outliers but there will not be a way to check if these are really outliers without the gold-standard.

31. Example
Need to clarify plausibility vs likelihood with respect to the outlier analysis.
Not Met: Thanks, I will make sure this issue is addressed.
Recommend involving 3 additional clinician raters.
Not Met: I have identified one rater (Dr. Emir Tas has agreed to be one of the three additional raters). I will continue to look for other clinician raters.

32. Quarterly Reporting Issues
Under RPPR B.2, What was accomplished under these goals:
Instructions: For this reporting period describe: 1) major activities; 2) specific objectives; 3) significant results, including major findings, developments, or conclusions (both positive and negative); and 4) key outcomes or other achievements. Include a discussion of stated goals not met.

33. Quarterly Reporting Issues
Instructions Continued: As the project progresses, the emphasis in reporting in this section should shift from reporting activities to reporting accomplishments. Goals are equivalent to specific aims. In the response, emphasize the significance of the findings to the scientific field. Include the approaches taken to ensure robust and unbiased results.

34. Quarterly Reporting Issues
Must address all 4 required elements:
Major activities
Specific Objectives
Significant results, including major findings, developments, or conclusions (both positive and negative)
Key Outcomes
Over time, this section should shift from reporting activities to reporting accomplishments

35. Quarterly Reporting Issues
In RPPR under B.4, What opportunities for training and professional development has the project provided:
Instructions: If the research is not intended to provide training and professional development opportunities or there is nothing significant to report during this reporting period, select "Nothing to Report."

36. Quarterly Reporting Issues
If working with a student or post-doc on your CCOP projects, complete the section in B4 about training and professional development opportunities provided to the students/post-docs on your project
Under Scientific Research Highlights:
Don’t report anything if you have no outcomes yet

37. Mentor-Mentee Development Plan