1. Poliomyelitis
Chris Berry

2. Polio is a childhood disease that was endemic until the 1880s
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3. Polio is transmitted by the oral-oral or fecal-oral route
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4. The “discovery” of polio occurred in two steps
Michael Underwood (1789)
Jakob Heine (1840)
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5. Karl Landsteiner, Erwin Poppin identified the virus that causes Polio in 1908
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6. Polio is a human enterovirus
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7. Viral Genome Capsid proteins RNA dependent RNA polymerase
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RNA dependent RNA polymerase
Capsid proteins
Proteins complex viral replication
Binds viral RNA, synthesis of + and – RNA
proteases

8. The polio virus will leave the cell 4-6 hours after full assembly
5-35 day incubation
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9. 95% of all polio cases are subclinical
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10. Clinical non-paralytic cases typically last 1-2 weeks
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11. Paralytic clinical infections occur less than1% of the time
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12. There is no cure for Polio
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13. Prevention is the key Jonas Salk creates first vaccine (1952)
Injected inactivated virus
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14. Prevention is the key Jonas Salk creates first vaccine (1952)
Injected inactivated virus
Albert Sabin creates second vaccine (1957)
Oral attenuated virus
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15. In 1988 there were over 350,000 cases in over 125 endemic countries
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16. To the Rescue Global Polio Eradication Initiative (1988)
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17. Troubles Arise

18. More than 351 million children from 40 different countries were immunized in 2009
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19. There were only 1,352 cases worldwide as of 2010
Total Cases
Year-to-date 2012
Year-to-date 2011
Total in 2011
Globally 25 55
650
-in endemic countries 24 18
341
-in non-endemic countries 1 37 79
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20. Photo - http://www. polioeradication

21. Information- http://www.polioeradication.org/Infectedcountries.aspx
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22. References WHO, Poliomyelitis Facts Sheet Wikipedia, Polio
Wikipedia, Polio
MedTV, Polio Transmission
Wikipedia, Poliomyelitis
Wikipedia, Poliovirus
Pub Med Health, Poliomyelitis
Aylward, R.B. Eradicating Polio: today’s challenges and tomorrow’s legacy.
Global Polio Eradication Initiative, Data
Global Polio Eradication Initiative, Infected Countries