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Tidal Volume Reduction in ARDS
James W Leatherman, M.D., F.C.C.P., Richard L. Lari, M.D., Conrad Iber, M.D., F.C.C.P., Arthur L. Ney, M.D. CHEST Volume 99, Issue 5, Pages (May 1991) DOI: /chest Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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FIGURE 1 Change in cardiac output (ΔQ percent) and change in PaO2 (Δ PaO2) following 200 ml VT reduction at 15 cm H2O of PEEP. CHEST , DOI: ( /chest ) Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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FIGURE 2 Change in cardiac output (Δ Q percent) vs change in static compliance (ΔCst) after 200 ml VT reduction at 15 cm H2O of PEEP CHEST , DOI: ( /chest ) Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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FIGURE 3 Hypothetical P-V curve with varying VT and PEEP At 0 PEEP and HiVT, ventilation occurs on the ascending limb of the P-V curve (α1→A2). After FRC has been increased with PEEP, the same HiVT causes ventilation to occur beyond the inflection point, on the flatter part of the P-V curve (B1→B2). Reduction in VT at HiPEEP results in ventilation to once again occur on the ascending limb (B1→A2). CHEST , DOI: ( /chest ) Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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