1. MultiBolus II™
Designed to address the unique Clinical Requirements & Needs of CPNB
April 2016

2. טיפול בכאב מבוא ורקע כללי
The Goal
Design an ergonomic mechanical Patient Control Analgesia [PCA] device for Continuous Peripheral Nerve Block [CPNB] that best stimulate (clinical efficiency wise) manual injection performed by the physician /nurse in compare with existing PCA devices (manual and electro-mechanical) 2

3. טיפול בכאב מבוא ורקע כללי
The Challenge
Flow rate of at-least 5ml/minute through a 21G catheter and in the range of 8ml/min to 10ml/min through a 19G catheter
Volume of at-least 5ml
Can be activated by “typical” 80 years old female
Semi automatic Automatically infuse the entire volume once activated
No parallel flow when device isn’t in active mode 3

4. טיפול בכאב מבוא ורקע כללי
The Expected Clinical Benifits
To obtain medication spread over at-least 180° of the nerve cord circumference
Efficient pain block is achieved when the at-least 180° of the targeted nerve cord is surrounded with the medication at about 10mm segment, while profound pain block is achieved with 360° medication surrounding 4

5. MultiBolus II™

6. טיפול בכאב מבוא ורקע כללי
Features
Tolerance
Value
Feature
At semi-automatic
+0.0 / -0.8ml
0, 3, 4, 5, 6
(option to re-set and permanent lock)
Volume
At Manual
+5% / -10%
±20%
[selected volume]/6
Lockout time (hr.)
±15%
With 21G; 6ml/minute
Velocity
With 20G; 9ml/minute
±10%
4 Kg (8.8 lb)
Activating Force
Hydraulic valve naturally closed
Prevent Parallel Flow
Priming of the bolus device: Not required in parallel administration [at the “cost” of partial volume (~1.5ml) during the first activation] 6

7. Parallel Administration

8. In-Linn Administration

9. On-Demand MultiBolus II™
comparative table
On-Demand
MultiBolus II™
Features
Parallel
In-line (without basal flow)
Administration
Fixed: 5 ml
3 to 6 ml (1ml stp)
Volume
5ml/hr, 10ml/hr
6 ml/hr
Lockout
Semi-Automatic
Activation
~ 1ml/minute
~ 6 ml/minute
Velocity (21G)
Small and compact
Large
Size
Medium
High (intuitive)
Ergonomic
Mechanical Valve (“clamp” type)
Hydraulic valve (normally closed)
Avoid parallel flow
Required
Not required
(for parallel version at the cost of ~1.5 ml in the first activation)
Priming of the bolus device
Compression with mechanical pumps
I-Flow, Select A Flow is sold actually for the C-Block (CPNB) only 9

10. The Hydraulic Valve
Safe Way to Eliminate Fault Parallel Flow that will result with Patient Over-Dose

11. Hydraulic Valve

12. Hydraulic Valve (cont.)
Normally closed hydraulic system;
The pressure in the pumps’ reservoir maintains the valve at closed position.
Valve is opened ONLY when the bolus device is activated; the pressure inside the device is higher then the pressure at the pumps reservoir

13. Thank You for Your Attention