1. Collagen
By: Maryam Behmanesh

2. making up from 25% to 35% of the whole-body protein content
Collagen :
The main structural protein in the extracellular space in the various connective tissues in animal bodies.
making up from 25% to 35% of the whole-body protein content
collagen tissues may be rigid (bone), compliant (tendon), or have a gradient from rigid to compliant (cartilage)

3. Collagen, in the form of elongated fibrils, is mostly found in :
Tendons
Ligaments
Skin
Corneas
Cartilage
Bones
Blood Vessels
Gut
Intervertebral discs
Dentin in teeth
Collagen, in the form of elongated fibrils, is mostly found in :

4. Types of collagen Fibrillar Non-fibrillar
(Type I, II, III, V, XI)
Non-fibrillar
FACIT: (Fibril Associated Collagens with Interrupted Triple Helixes)
Short chain
Basement membrane
Multiplexin(Multiple Triple Helix domains with Interruptions)
MACIT (Membrane Associated Collagens with Interrupted Triple Helices)
Other

5. The five most common types are:
Type I: skin, tendon, vascular ligature, organs, bone
 (main component of the organic part of bone)
Type II: cartilage
(main collagenous component of cartilage)
Type III: reticulate
(main component of reticular fibers,commonly found alongside type I.)
Type IV: forms basal lamina, the epithelium-secreted layer of the basement membrane.
Type V: cell surfaces, hair and placenta

6. Fig1: Proline hydroxylation of oxygen assisted by
Prulyl hydroxylase enzyme and vitamin C (ascorbate(

7. Fig2: Carbohydrate units in the building of collagen

8. Fig3: The formation of collagen by procollagen sequence into Tropo procollagen peptidase enzymes.

9. Fig4: How to get Tropocollagen fields

10. Fig5:Bandolly production and R Lyzynonor between two lysine and leucine Tropo procollagen connection to each other.

11. Fig6: The synthesis steps os collagen
Synthesized polypeptide sequence
Hydrocsillation of Prolin & Lysine
Gllicozilation of Lysine
Production of procollagen

12. Diseases
Epidermolysis bullosa junctional Epidermolysis bullosa Motation in XVII collagen Defective collagen type VII

13. Ehlers–Danlos syndrome

14. Real-time atomic force microscopy imaging of collagen fibril under ultraviolet irradiation [Young-Sang Youn,Sehun Kim(2016)]

15. Metalloproteinase

16. Collagen products maker