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Cardiac Troponin and its Relationship to Cardiovascular Outcomes in Community Populations – A Systematic Review and Meta-analysis  Julie Sze, MBBS, John.

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Presentation on theme: "Cardiac Troponin and its Relationship to Cardiovascular Outcomes in Community Populations – A Systematic Review and Meta-analysis  Julie Sze, MBBS, John."— Presentation transcript:

1 Cardiac Troponin and its Relationship to Cardiovascular Outcomes in Community Populations – A Systematic Review and Meta-analysis  Julie Sze, MBBS, John Mooney, MBBS, Federica Barzi, PhD, Graham S. Hillis, MBChB, PhD, Clara K. Chow, MBBS, PhD  Heart, Lung and Circulation  Volume 25, Issue 3, Pages (March 2016) DOI: /j.hlc Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Terms and Conditions

2 Figure 1 Flow Diagram. Heart, Lung and Circulation  , DOI: ( /j.hlc ) Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Terms and Conditions

3 Figure 2 Adjusted* relative risk (RR) of cardiovascular events and all-cause mortality associated with troponin greater than the 99th percentile reference value of a healthy reference population versus undetected troponin at baseline. *Adjusted for age, gender and race, smoking status, BMI, presence of diabetes mellitus, total cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication use. Additional adjustments include: Saunders: hs-CRP, BNP and eGFR. deFilippi: CVD mortality model- coronary heart disease, CRP, NT-proBNP. HF model - albumin and creatinine concentration coronary heart disease, heart rate, and left ventricle hypertrophy on electrocardiogram. de Lemos: hs-CRP, GFR, NT-proBNP. Leistner: hscRP, NT-proBNP,eGFR. Sundstrom: previous myocardial infarction (MI), MI during follow up, NT-proBNP. Zethelius: lipid lowering treatment Heart, Lung and Circulation  , DOI: ( /j.hlc ) Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Terms and Conditions

4 Figure 3 Adjusted* relative risk (RR) for cardiovascular mortality in individuals with detectable troponin levels versus individuals with undetectable levels. * Adjusted for age, gender and race, smoking status, BMI, presence of diabetes mellitus, total cholesterol, HDL cholesterol, systolic blood pressure, antihypertensive medication use. Additional adjustments included: Everett: BMI, history of MI, hsCRP, NT-BNP, GFR. Daniels: BMI, heart rate, physical activity, and creatinine clearance, baseline CHD. Heart, Lung and Circulation  , DOI: ( /j.hlc ) Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Terms and Conditions

5 Figure 4 Adjusted relative risk (RR) of adverse outcome stratified by troponin categorisation (increasing troponin levels). Heart, Lung and Circulation  , DOI: ( /j.hlc ) Copyright © 2015 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ) Terms and Conditions


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