1. Stroke
John C. Stevenson
Martin Birkhäuser
Alfred O. Mueck

2. Stroke 1. Risk factors, absolute risks 2. MHT – WHI, RCTs
3. MHT – Observational Studies
4. Tibolone, SERMs
5. Experimental Research
6. Stroke prevention, Guidelines, Consensus Statement
Structure of this presentation!

3. Stroke 1. Risk factors, absolute risks 2. MHT – WHI, RCTs
3. MHT – Observational Studies
4. Tibolone, SERMs
5. Experimental Research
6. Stroke prevention, Guidelines, Consensus Statement

4. Increased stroke risk Age History/family history Prior stroke, TIA, MI
Atrial fibrillation
Gender
Incidence greater in males
Mortality greater in females
Hypertension
Smoking
Diabetes mellitus
Arterial disease
Carotid, peripheral, coronary
Lifestyle
diet, exercise
Besides age are hypertension and smoking the morst important risk factors.

5. Stroke Ischemic (thrombotic/embolic) 86% Hemorrhagic Intracerebral 10%
Subarachnoid 4%
The diagnosis to differ between ischemic stroke and hemorraghic stroke must be made as soon as possible by computertomography. MHT is a risk factor for ischemic stroke.

6. Female stroke prevalence USA females, 2004