1. Intercellular Communication
Overview

3. Autocrine
AKA: Juxtacrine

4. Endocrine

5. Paracrine, Autocrine
Nervous
Juxtacrine

6. Same signal  Many different effects
Different Receptors
Different Intracellular Events
Same signal  Many different effects

9. ACTIVITY

10. Signaling Through Intracellular Receptors
Hydrophobic Signaling Molecules

11. nitric oxide

13. Transcription Factor

14. Enzyme

15. Signaling Through Surface Receptors
Hydrophilic Signaling Molecules

16. epidermal growth factor
peach lactone
histamine
insulin
acetylcholine

18. messengers

19. Amplify
Signal Transduction

21. Ligand-gated channels

22. Enzyme & Enzyme-linked Receptors
Receptor Tyrosine Kinases

23. (Receptor Tyrosine Kinase)
E.g., Epidermal Growth Factor (EGF)
Insulin
IGF, FGF, HGF, PDGF P
Cross-Phosphorylation
(Receptor Tyrosine Kinase)

25. Protein Domain
Binding Partner
Structure
SH2 (Src Homology 2)
Phosphotyrosine
SH3 (Src Homology 3)
Poly-Proline
PH (Plekstrin Homology)
Phospho-Phosphotidylinositol
(PI2P, PI3P)
PTB (Phosphotyrosine Binding)

27. Ras Activation

28. EGF SH2 SH3 Son of Sevenless (SOS; a GNEF for Ras) Grb2
(an adapter protein)
Son of Sevenless (SOS; a GNEF for Ras)

29. Cell Division

30. PI Kinase Activation

31. Phosphatidylinositol Kinase

32. PH PH

33. PH PH

35. AKT

37. G-Protein Linked Receptors
GPCRs

40. Extracellular Space

43. Ion Channel Activationbg

45. Adenylyl Cyclase Activation

46. adenylyl cyclase

48. adenylyl cyclase
ATP
cAMP

49. (protein kinase A)

52. Phospholipase C Activation