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Prevention of paraplegia during thoracic aortic cross-clamping: Importance of patent internal mammary arteries  Joseph S. Giglia, MD, Gerald B. Zelenock,

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Presentation on theme: "Prevention of paraplegia during thoracic aortic cross-clamping: Importance of patent internal mammary arteries  Joseph S. Giglia, MD, Gerald B. Zelenock,"— Presentation transcript:

1 Prevention of paraplegia during thoracic aortic cross-clamping: Importance of patent internal mammary arteries  Joseph S. Giglia, MD, Gerald B. Zelenock, MD, Louis D'Alecy, DMD, PhD  Journal of Vascular Surgery  Volume 19, Issue 6, Pages (June 1994) DOI: /S (94) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

2 Fig. 1 A, Three-dimensional schematic representation of IMA-ICA-ASA connection. Blood flows from IMA, dorsally along ICAs to anterior radicular artery (ARA), and then to anterior spinal artery (ASA). B, Two transverse sections from A. Note unilateral ARA at level 1 and lack of ARA at level 2. Arrows indicate where ICAs were surgically divided. Ao is aorta, PSA is posterior spinal artery, and SC is spinal cord. Journal of Vascular Surgery  , DOI: ( /S (94) ) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

3 Fig. 2 Neurologic deficit score for animals with IMA intact (IMA-IN, white bars) and IMA divided (IMA-OUT, black bars) is compared at 1, 4, 18, 24, and 48 hours after extubation. Results are plotted ±SEM. Asterisk indicates statistical significance at p< Exact p values for comparisons at 1, 4, 18, and 24 hours are p = , p = , p = , p = , respectively. No neurologic deficit score statistical comparison was possible at 48 hours because all IMA-OUT animals were dead. Journal of Vascular Surgery  , DOI: ( /S (94) ) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

4 Fig. 3 Survival is compared between IMA-intact (IMA-IN) and IMA-divided (IMA-OUT) animals with product-limit survival estimate. Solid line represents IMA-IN animals and dotted line represents IMA-OUT animals. Difference was statistically significant with p = SDF is survival distribution function. Journal of Vascular Surgery  , DOI: ( /S (94) ) Copyright © 1994 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

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