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Table 1 Characteristics of study population, by pneumococcal vaccination status. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death,

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Presentation on theme: "Table 1 Characteristics of study population, by pneumococcal vaccination status. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death,"— Presentation transcript:

1 Table 1 Characteristics of study population, by pneumococcal vaccination status.
From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

2 Figure 1 In-hospital survival among individuals admitted to hospitals with diagnosed community-acquired pneumonia. Differences in vaccination status were associated with significant differences in survival. The solid line represents individuals with known prior pneumococcal vaccination, the dashed line represents individuals with unknown vaccination status, and the dotted line represents unvaccinated individuals. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

3 Table 2 Effect of prior pneumococcal vaccination on all-cause in-hospital mortality under varying assumptions about individuals with unknown vaccination status. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

4 Figure 2 Crude in-hospital survival among individuals admitted for community-acquired pneumonia, stratified by Pneumonia Outcomes Research Team (PORT) classification [30]. For all but those with the lowest score (PORT class I), a record of prior pneumococcal vaccination was associated with reduced likelihood of in-hospital mortality. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

5 Figure 3 Subgroup analyses of adjusted relative risk of death among individuals with community-acquired pneumonia and a record of prior pneumococcal vaccination (PV). Heterogeneity of effects of vaccination was not seen with stratification by Pneumonia Outcomes Research Team (PORT) scores [30], record of influenza vaccination (IFV), or age, but vaccination appeared to be significantly more effective in reducing early death than in reducing late death. Relative risk was approximated by ORs for all analyses except for that of hospitalization duration, for which relative risk is represented by hazard ratios. Results are plotted on a common log scale. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

6 Table 3 Cox proportional hazards model demonstrating effect of pneumococcal vaccination on relative hazard of death, by duration of hospitalization. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

7 Figure 4 Adjusted ORs for record of complications of hospitalization, under varying assumptions about pneumococcal vaccination in individuals with unknown vaccination status. Shown are data with individuals with unknown status excluded (blackened circles), individuals with unknown status assumed to be unvaccinated (open circles), individuals with unknown status assumed to be vaccinated (blackened squares), and unknown status randomly replaced (open squares). Estimates were generated using logistic regression models that controlled for Pneumonia Outcomes Research Team (PORT) scores, concurrent influenza vaccination, other medical comorbidities, smoking status, and community hospital care, as appropriate. Results are plotted on a common log scale. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

8 Figure 5 Seasonality of effect of prior pneumococcal vaccination on mortality, estimated using a logistic regression model with an interaction term based on the cosine of month. The observed effect of vaccination is greatest during months when invasive pneumococcal disease is most common in the United States [40]. From: Prior Pneumococcal Vaccination Is Associated with Reduced Death, Complications, and Length of Stay among Hospitalized Adults with Community-Acquired Pneumonia Clin Infect Dis. 2006;42(8): doi: /501354 Clin Infect Dis | © 2006 by the Infectious Diseases Society of America

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