1. From: Functional and Structural Changes in a Canine Model of Hereditary Primary Angle-Closure Glaucoma
Invest. Ophthalmol. Vis. Sci ;51(1): doi: /iovs
Figure Legend:
(A) Cross-section histology of the healthy (control) canine optic nerve 1 mm posterior to the laminar region. Arrow: large axonal profile in the healthy optic nerve. (B) Cross-section histology of the optic nerve 1 mm posterior to the laminar region from one colony of glaucomatous Basset Hounds (30 months of age; IOP at the time of eye removal was 36 mm Hg). Massive degeneration of predominantly large axons is evident. Some axons are extremely swollen and enlarged (closed arrow). Excessive glial proliferation/hypertrophy (open arrow) and thickening of septa can be observed between axon bundles and within axon bundles in this section. Observed axonal loss was of rather diffuse nature, and images of both eyes were collected from the superior central portion of the optic nerve, where thickening of the laminar septa appeared most prominent.
Date of download: 11/12/2017
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