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The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99:249-256.

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Presentation on theme: "The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99:249-256."— Presentation transcript:

1 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Fig. 1. CONSORT diagram for the selection process of the included studies. * Studies including patients with localized prostate cancer (T1-2, N0) were considered not eligible. ** Two publications for the same author were included as they reported on different cohorts [6,10]. © 2017 S. Karger AG, Basel

2 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Fig. 2. Forest and funnel plots of the impact of RP with or without adjuvant therapy on OS and DSS in comparison to other options not including RP. © 2017 S. Karger AG, Basel

3 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Fig. 3. Forest and funnel plots for the impact of adjuvant therapy on survival after RP. a Impact of adjuvant HT on OS and DSS. b Impact of adjuvant RT on DSS. © 2017 S. Karger AG, Basel

4 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Fig. 4. Forest and funnel plots of the impact of combination of RT and HT on OS and DSS vs. RT or HT as a monotherapy. © 2017 S. Karger AG, Basel

5 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Table 1. Summary of the included studies © 2017 S. Karger AG, Basel

6 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Table 2. Summary of the outcomes of the included studies © 2017 S. Karger AG, Basel

7 The Role of Radical Prostatectomy and Radiotherapy in Treatment of Locally Advanced Prostate Cancer: A Systematic Review and Meta-Analysis Urol Int 2017;99: DOI: / Table 3. Newcastle Ottawa Scale for risk of bias assessment of the included studies (scores ≥7-9, 4-6, <4 are considered as low, intermediate, and high risk, respectively) © 2017 S. Karger AG, Basel

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