1. Haixu Tang School of Informatics
DNA replication
Haixu Tang
School of Informatics

2. DNA replication and heredity

3. Mutation rate Low Correction mechanism
E.Coli & human: 1 in 109 bases
Correction mechanism
Experiment measure of mutation rate
Many mutations are deleterious and eliminated by natural selection

4. Mutation rates are different from protein to protein

5. Reaction of DNA replication

7. The semiconservative DNA replication

8. Replication forks

9. An incorrect model

10. Correct model

11. Exonucleolytic Proofreading of polymerase

13. Why always 5’3’?

14. Correct model

15. Primase

16. DNA synthesis of lagging strand

17. DNA ligation

18. DNA helicase

19. Regulated sliding clamp

20. A complete picture of lagging strand synthesis

21. DNA repair

22. DNA replication in eukaryotes

23. Initiation of DNA replication

24. Origin of DNA Replication
Bacterial Chromosomes Have a Single Origin of DNA Replication
Eucaryotic Chromosomes Contain Multiple Origins of Replication
Replication Origins in a Simple Eucaryote, the Budding Yeast is identified
The Mammalian DNA Sequences That Specify the Initiation of Replication Have Been Difficult to Identify

25. DNA replication in cell cycle

26. Telomerase Replicates the Ends of Chromosomes

27. Spontaneous alterations in DNA

28. DNA repair

29. DNA recombination

30. Site-specific recombination