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Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components.

Published byJulian Patrick Arnold Modified over 6 years ago

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Presentation on theme: "Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components."— Presentation transcript:

1 Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components Dermatopathology 2017;4: DOI: / Fig. 1. Hybrid schwannoma and perineurioma. Nodular lesion of the scalp (a). Whole-mount of the lesion: a multinodular dermal growth with heterogenous areas (b, scanning magnification), including a schwannomatous component with plump-spindled cells arranging in Antoni A and Antoni B areas (c, original magnification ×100), and hypocellular myxoid areas with slender-spindled cells corresponding to the perineurial component (d, original magnification ×100). Diffuse S100 protein expression in the schwannomatous component (e, original magnification ×50). Focal epithelial membrane antigen expression in the perineurial component (f, original magnification ×400). © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

2 Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components Dermatopathology 2017;4: DOI: / Fig. 2. Hybrid schwannoma and neurofibroma. Nodular lesion of the ankle (a). Scanning magnification showing a multinodular dermal lesion (b), with a schwannomatous component in the center of one nodule (right) surrounded by a neurofibromatous component (left) (c, original magnification ×100). Diffuse S100 protein expression in the schwannomatous component, with only partial expression in the neurofibroma (d, original magnification ×50). CD34 highlighting the neurofibromatous component but negative in the schwannomatous nodule (e, original magnification ×50). Epithelial membrane antigen highlighting the capsule at the periphery of the lesion (f, original magnification ×200). © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

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