Presentation is loading. Please wait.

Presentation is loading. Please wait.

Application of moisturizer to neonates prevents development of atopic dermatitis  Kenta Horimukai, MD, Kumiko Morita, MD, Masami Narita, MD, PhD, Mai Kondo,

Published byMarcus Lynch Modified over 6 years ago

Similar presentations

Presentation on theme: "Application of moisturizer to neonates prevents development of atopic dermatitis  Kenta Horimukai, MD, Kumiko Morita, MD, Masami Narita, MD, PhD, Mai Kondo,"— Presentation transcript:

1 Application of moisturizer to neonates prevents development of atopic dermatitis 
Kenta Horimukai, MD, Kumiko Morita, MD, Masami Narita, MD, PhD, Mai Kondo, MD, Hiroshi Kitazawa, MD, PhD, Makoto Nozaki, MD, Yukiko Shigematsu, MD, Kazue Yoshida, MD, PhD, Hironori Niizeki, MD, PhD, Ken-ichiro Motomura, MD, Haruhiko Sago, MD, PhD, Tetsuya Takimoto, MD, PhD, Eisuke Inoue, PhD, Norio Kamemura, PhD, Hiroshi Kido, MD, PhD, Junzo Hisatsune, PhD, Motoyuki Sugai, DDS, PhD, Hiroyuki Murota, MD, PhD, Ichiro Katayama, MD, PhD, Takashi Sasaki, PhD, Masayuki Amagai, MD, PhD, Hideaki Morita, MD, PhD, Akio Matsuda, PhD, Kenji Matsumoto, MD, PhD, Hirohisa Saito, MD, PhD, Yukihiro Ohya, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 134, Issue 4, Pages e6 (October 2014) DOI: /j.jaci Copyright © 2014 The Authors Terms and Conditions

2 Fig 1 Study design. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

3 Fig 2 Study flow chart. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

4 Fig 3 Proportions of infants who did not have AD/eczema. Kaplan-Meier plots show the proportions of infants in the intervention (circle) and control (triangle) groups with AD/eczema during the first 32 weeks of life. The log-rank test indicated statistically significant differences between groups (P = .012). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

5 Fig E1 Correlation of allergen-specific IgE values determined by using a DLC chip system and CAP-FEIA. The values of anti-egg white (A), anti-ovomucoid (B), and anti-milk (C) IgE antibodies derived from 72, 48, and 29 infants, respectively, could be determined by using both the CAP-FEIA and DLC chip methods, and the correlations between these values obtained from the same samples were tested by means of linear regression analysis. BUe, Binding unit of IgE. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

6 Fig E2 Allergic sensitization at weeks 12 and 32: comparison between the intervention and control groups. The serum levels of egg white–specific IgE (binding unit of IgE [BUe]/mL) in infants at weeks 12 and 32 were measured with a DLC chip and converted into CAP-FEIA equivalents (kUA/L) by using a previously described method.E3 Note that high correlation between these 2 data sets with the present samples was confirmed only at week 32. The values obtained from AD/eczema-positive infants are shown in warm colors, and those from AD/eczema-negative infants are shown in cold colors. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

7 Fig E3 Stratum corneum hydration (SCH) change in the lower leg (A) and forehead (B) in each group. SCH values (relative impedance) on the outside of the lower leg (Fig E3, A) and forehead (Fig E3, B) were shown at baseline (week 0) and at 4, 12, 24, and 32 weeks of age. Symbols (circles and triangles) and bars stand for means and SDs. SCH values were significantly higher for the lower leg in the intervention group at 12 weeks of age compared with those in the control group (P < .05, ANOVA). Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

8 Fig E4 Allergic sensitization at weeks 12 and 32. Serum levels of egg white–specific IgE (binding unit of IgE [BUe]/mL) in infants at weeks 12 and 32 were measured with a DLC chip and converted into CAP-FEIA equivalents (kUA/L). A, The AD/eczema-positive group had a higher proportion of infants sensitized with egg white at 0.35 kUA/L CAP-FEIA equivalents at week 32 compared with the other group (P = .043). B, The skin lesion–positive group had a higher proportion of infants sensitized with egg white at 0.70 kUA/L CAP-FEIA equivalent at week 12 (P = .0059) and week 32 (P = .0017) compared with the other group. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2014 The Authors Terms and Conditions

Download ppt "Application of moisturizer to neonates prevents development of atopic dermatitis  Kenta Horimukai, MD, Kumiko Morita, MD, Masami Narita, MD, PhD, Mai Kondo,"

Similar presentations

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,

Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever  Laura Hatzler, Valentina Panetta,
Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan  Akiko Yagami, MD, PhD, Michiko Aihara, MD, PhD, Zenro Ikezawa,

Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan  Akiko Yagami, MD, PhD, Michiko Aihara, MD, PhD, Zenro Ikezawa,
Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.

Repeated low-dose intradermal allergen injection suppresses allergen-induced cutaneous late responses  Giuseppina Rotiroti, MD, Mohamed Shamji, PhD, Stephen.
Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies  Marija Geroldinger-Simic, MD, Thomas Zelniker,

Birch pollen–related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies  Marija Geroldinger-Simic, MD, Thomas Zelniker,
Evaluation and treatment of allergic fungal sinusitis. II

Evaluation and treatment of allergic fungal sinusitis. II
Ovomucoids IgE is a better marker than egg white–specific IgE to diagnose boiled egg allergy  Yasuhiro Haneda, MD, PhD, Naoyuki Kando, MD, Masahiro Yasui,

Ovomucoids IgE is a better marker than egg white–specific IgE to diagnose boiled egg allergy  Yasuhiro Haneda, MD, PhD, Naoyuki Kando, MD, Masahiro Yasui,
Low-affinity allergen-specific IgE in cord blood and affinity maturation after birth  Norio Kamemura, PhD, Norio Kawamoto, MD, PhD, Ryosuke Nakamura, PhD,

Low-affinity allergen-specific IgE in cord blood and affinity maturation after birth  Norio Kamemura, PhD, Norio Kawamoto, MD, PhD, Ryosuke Nakamura, PhD,
Anthroposophic lifestyle is associated with a lower incidence of food allergen sensitization in early childhood  Sara Fagerstedt, MSc, Helena Marell Hesla,

Anthroposophic lifestyle is associated with a lower incidence of food allergen sensitization in early childhood  Sara Fagerstedt, MSc, Helena Marell Hesla,
Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features  Hideaki Morita, MD, PhD, Hiroko Suzuki,

Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features  Hideaki Morita, MD, PhD, Hiroko Suzuki,
High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,

High-titer IgE antibody specific for pollen allergens in northern California is associated with both wheezing and total serum IgE  Elizabeth A. Erwin,
Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD 
Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.

Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy  Michael Kulis, PhD, Katie.
Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A

Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A
Ann-Marie M. Schoos, MD, PhD, Jacob D

Ann-Marie M. Schoos, MD, PhD, Jacob D
Evaluation and treatment of allergic fungal sinusitis. II

Evaluation and treatment of allergic fungal sinusitis. II
Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 

Julie Wang, MD, James H. Godbold, PhD, Hugh A. Sampson, MD 
Application of moisturizer to neonates prevents development of atopic dermatitis  Kenta Horimukai, MD, Kumiko Morita, MD, Masami Narita, MD, PhD, Mai Kondo,

Application of moisturizer to neonates prevents development of atopic dermatitis  Kenta Horimukai, MD, Kumiko Morita, MD, Masami Narita, MD, PhD, Mai Kondo,
Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features  Hideaki Morita, MD, PhD, Hiroko Suzuki,

Food protein–induced enterocolitis syndromes with and without bloody stool have distinct clinicopathologic features  Hideaki Morita, MD, PhD, Hiroko Suzuki,
Children with allergic and nonallergic rhinitis have a similar risk of asthma  Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,

Children with allergic and nonallergic rhinitis have a similar risk of asthma  Bo Lund Krogsgaard Chawes, MD, Klaus Bønnelykke, MD, PhD, Eskil Kreiner-Møller,
No evidence of intrauterine sensitization against inhalant allergens

No evidence of intrauterine sensitization against inhalant allergens

Similar presentations

Ads by Google