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The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency  Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona.

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Presentation on theme: "The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency  Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona."— Presentation transcript:

1 The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency 
Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona Donnanno, MD, Vanessa Guazzi, MD, Annarosa Soresina, MD, Antonella Meini, MD, Alessandro Plebani, MD, Fernando Aiuti, MD, Isabella Quinti, MD  Journal of Allergy and Clinical Immunology  Volume 115, Issue 2, Pages (February 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Identification of mature, IgM memory, and switched memory B cells by means of 4-color fluorescence. A, The expression of CD22 and CD27 discriminates CD22+CD27− mature B cells and CD22+CD27+ memory B cells (top panels). Memory B cells can be divided into IgM memory (IgMbrightIgDdull) and switched memory (IgM−IgD−) B cells. B, Distribution of B-cell subsets in control subjects and patients with CVID shown as a pie graph: mature (white), IgM memory (black), and switched memory (gray) B cells. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Percentage of total B cells (A). The relative frequency of each subset within the B-cell compartment is shown as a box plot for mature (B), memory (C), switched (D), and IgM memory (E) B cells. Data are shown as box plots. Boxes represent values between the 25th and 75th percentiles. The horizontal line corresponds to the median. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Serum concentrations of IgM anti-PnPS type 14 (A). Plot showing the level of IgM anti-PnPS and the frequency of IgM memory B cells in group 1 (black dot) and 2 (white dot) patients (B). Note that dots representing patients with identical values overlap. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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