1. Mechanism of NO synthesis
Mechanism of NO synthesis. NOS catalyzes a five-electron oxidation of a guanidine nitrogen of L-arginine to generate NO and L-citrulline. L-Hydroxyarginine is formed as an intermediate that is tightly bound to the enzyme. Both steps in the reaction are dependent on calcium and calmodulin and are enhanced by tetrahydrobiopterin.
Source: Nitric Oxide Synthases, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: November 12, 2017
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